AIMS: Most acute coronary syndromes are caused by plaque rupture. The risk of plaque rupture is related to plaque composition. The purpose of this study was to validate VH-IVUS for in vivo plaque characterisation. METHODS AND RESULTS: Six rabbits were fed a cholesterol-supplemented diet for 12 to 18 months. Thereafter, VH-IVUS imaging of the aorta was performed. After sacrifice, the VH-IVUS images were matched to the corresponding histological cross sections. A total of 260 atherosclerotic plaques were analysed. VH-IVUS had a high sensitivity, specificity and positive predictive value for the detection of non-calcified thin cap fibroatheroma (88%, 96%, 87%, respectively) and calcified thin cap fibroatheroma (95%, 99%, 93%, respectively). These values were respectively 82%, 94%, 85% for non-calcified fibroatheroma and 78%, 98%, 84% for calcified fibroatheroma. The lowest values were obtained for pathological intimal thickening (74%, 92%, 70%, respectively). For all plaque types, VH-IVUS had a kappa-value of 0.79. Linear regression analysis and Bland-Altman plots showed a strong correlation between VH-IVUS and histology for fibrous tissue, fibrofatty tissue, necrotic calcified tissue and confluent necrotic core. CONCLUSIONS: VH-IVUS showed a good accuracy for in vivo plaque characterisation and is a promising technique for the detection of the vulnerable plaque.
AIMS: Most acute coronary syndromes are caused by plaque rupture. The risk of plaque rupture is related to plaque composition. The purpose of this study was to validate VH-IVUS for in vivo plaque characterisation. METHODS AND RESULTS: Six rabbits were fed a cholesterol-supplemented diet for 12 to 18 months. Thereafter, VH-IVUS imaging of the aorta was performed. After sacrifice, the VH-IVUS images were matched to the corresponding histological cross sections. A total of 260 atherosclerotic plaques were analysed. VH-IVUS had a high sensitivity, specificity and positive predictive value for the detection of non-calcified thin cap fibroatheroma (88%, 96%, 87%, respectively) and calcified thin cap fibroatheroma (95%, 99%, 93%, respectively). These values were respectively 82%, 94%, 85% for non-calcified fibroatheroma and 78%, 98%, 84% for calcified fibroatheroma. The lowest values were obtained for pathological intimal thickening (74%, 92%, 70%, respectively). For all plaque types, VH-IVUS had a kappa-value of 0.79. Linear regression analysis and Bland-Altman plots showed a strong correlation between VH-IVUS and histology for fibrous tissue, fibrofatty tissue, necrotic calcified tissue and confluent necrotic core. CONCLUSIONS: VH-IVUS showed a good accuracy for in vivo plaque characterisation and is a promising technique for the detection of the vulnerable plaque.
Authors: Shann S Yu; Ryan A Ortega; Brendan W Reagan; John A McPherson; Hak-Joon Sung; Todd D Giorgio Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2011-08-10
Authors: Max L Olender; Lambros S Athanasiou; Lampros K Michalis; Dimitris I Fotiadis; Elazer R Edelman Journal: IEEE J Sel Top Signal Process Date: 2020-06-15 Impact factor: 6.856
Authors: Gurpreet Singh Sandhu; Luis Solorio; Ann-Marie Broome; Nicolas Salem; Jeff Kolthammer; Tejas Shah; Chris Flask; Jeffrey L Duerk Journal: Wiley Interdiscip Rev Syst Biol Med Date: 2010 Jul-Aug
Authors: Jennifer Huisman; Rasmus Egede; Adam Rdzanek; Dirk Böse; Raimund Erbel; Janusz Kochman; Lisette Okkels Jensen; Job van der Palen; Marc Hartmann; Gary S Mintz; Clemens von Birgelen Journal: Int J Cardiovasc Imaging Date: 2012-01-14 Impact factor: 2.357
Authors: Hector M Garcìa-Garcìa; Bill D Gogas; Patrick W Serruys; Nico Bruining Journal: Int J Cardiovasc Imaging Date: 2011-02-17 Impact factor: 2.357
Authors: Jennifer Huisman; Marc Hartmann; Gary S Mintz; Gert K van Houwelingen; Martin G Stoel; Frits H A F de Man; Hans W Louwerenburg; Clemens von Birgelen Journal: Int J Cardiovasc Imaging Date: 2011-03-19 Impact factor: 2.357