Literature DB >> 19577543

CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha.

Xiaohuan Guo1, Ting Li, Yu Wang, Luning Shao, Yingmei Zhang, Dalong Ma, Wenling Han.   

Abstract

Our previous data show that CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is a potential tumor suppressor gene, but its function in pancreatic cancer is unknown. Herein we first report that CMTM5 is also absent in pancreatic cancer cell lines with promoter methylation. Compared with normal pancreatic tissues, CMTM5 is significantly decreased in cancer tissues. Restoration of CMTM5-v1 not only induces MIA PaCa-2 cell apoptosis with activation of caspase 3, 8 and 9, but also has synergistic effects with TNF-alpha. Thus, CMTM5 may play a role in the pancreatic cancer.

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Year:  2009        PMID： 19577543     DOI： 10.1016/j.bbrc.2009.06.148

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

1.  CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo.

Authors:  Y Xiao; Y Yuan; Y Zhang; J Li; Z Liu; X Zhang; Z Sheng; T Xu; X Wang
Journal:  Clin Transl Oncol       Date:  2014-11-12       Impact factor: 3.405

2.  Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer.

Authors:  Zhikun Liang; Jingwen Xie; Lihong Huang; Yaoyao Huang; Yuwen Zhang; Ruanxin Ma; Zhuoling Zheng; Qinbo Wang; Xiaoyan Li
Journal:  J Gastrointest Oncol       Date:  2021-04

3.  Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology.

Authors:  Elham Abedi; Mehran Karimi; Ramin Yaghobi; Hamid Mohammadi; Sezaneh Haghpanah; Mohamad Moghadam; Elahe Bayat; Alireza Rezvani; Mani Ramzi
Journal:  J Clin Lab Anal       Date:  2022-02-17       Impact factor: 2.352

4.  CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.

Authors:  Ting Li; Yingying Cheng; Pingzhang Wang; Wenyan Wang; Fengzhan Hu; Xiaoning Mo; Hongxia Lv; Tao Xu; Wenling Han
Journal:  J Exp Clin Cancer Res       Date:  2015-10-16

5.  CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis.

Authors:  Bing Cai; Yunbei Xiao; Yeping Li; Shaobin Zheng
Journal:  Oncol Lett       Date:  2017-06-08       Impact factor: 2.967

Review 6.  CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value.

Authors:  Jie Wu; Lan Li; Siyi Wu; Bin Xu
Journal:  Cancer Biol Med       Date:  2020-08-15       Impact factor: 4.248

7.  CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis.

Authors:  Zesong Li; Jun Xie; Jianting Wu; Wenjie Li; Liping Nie; Xiaojuan Sun; Aifa Tang; Xianxin Li; Ren Liu; Hongbing Mei; Feng Wang; Zhiping Wang; Yaoting Gui; Zhiming Cai
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240

8.  CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.

Authors:  Baocai Liu; Yu Su; Ting Li; Wanqiong Yuan; Xiaoning Mo; Henan Li; Qihua He; Dalong Ma; Wenling Han
Journal:  Oncotarget       Date:  2015-12-01

9.  CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling.

Authors:  Gang Xu; Chengxue Dang
Journal:  Cancer Cell Int       Date:  2017-11-29       Impact factor: 5.722

10.  [Pathophysiologic mechanism of CMTM5 low expression in multiple myeloma progression].

Authors:  Y Ma; J F Shi; H Y Qiu; J Yuan; Y Zhang; P Zhou; J J Xu; Q Z Han
Journal:  Zhonghua Xue Ye Xue Za Zhi       Date:  2019-01-14
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