Literature DB >> 19577357

The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion.

V Ashley Cantrell1, Jason R Jessen.   

Abstract

Van Gogh-Like 2 (VANGL2) is a planar cell polarity protein essential for collective migration during embryonic development, yet its contribution to tumor cell motility and invasion are unknown. We report for the first time that loss of VANGL2 in human cancer cells promotes efficient collective and directed migration and matrix metalloproteinase (MMP)-dependent ECM invasion. We show that VANGL2 knockdown cells exhibit increased activation of secreted MMP2, higher levels of membrane-localized MMP14, and decreased cell-surface fibronectin. These important findings support the notion that planar cell polarity proteins act in coordination with known regulators of cancer cell migration to influence invasion and perhaps metastasis. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19577357     DOI： 10.1016/j.canlet.2009.05.041

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  27 in total

1.  Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

Authors:  Vladislav S Golubkov; Alexander E Aleshin; Alex Y Strongin
Journal:  J Biol Chem       Date:  2011-04-25       Impact factor: 5.157

2.  Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development.

Authors:  Wendy S Beane; Ai-Sun Tseng; Junji Morokuma; Joan M Lemire; Michael Levin
Journal:  Stem Cells Dev       Date:  2012-03-23       Impact factor: 3.272

Review 3.  Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer.

Authors:  Jason Hatakeyama; Jessica H Wald; Ignat Printsev; Hsin-Yi Henry Ho; Kermit L Carraway
Journal:  Endocr Relat Cancer       Date:  2014-06-30       Impact factor: 5.678

Review 4.  Targeting Wnt pathways in disease.

Authors:  Zachary F Zimmerman; Randall T Moon; Andy J Chien
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-11-01       Impact factor: 10.005

5.  Structural and temporal requirements of Wnt/PCP protein Vangl2 function for convergence and extension movements and facial branchiomotor neuron migration in zebrafish.

Authors:  Xiufang Pan; Vinoth Sittaramane; Suman Gurung; Anand Chandrasekhar
Journal:  Mech Dev       Date:  2013-12-09       Impact factor: 1.882

Review 6.  Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.

Authors:  Tura C Camilli; Ashani T Weeraratna
Journal:  Biochem Pharmacol       Date:  2010-03-06       Impact factor: 5.858

7.  VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.

Authors:  Tammy N Jessen; Jason R Jessen
Journal:  Exp Cell Res       Date:  2018-11-22       Impact factor: 3.905

8.  Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway.

Authors:  Sudipta Basu; Bernhard Ellinger; Stefano Rizzo; Céline Deraeve; Markus Schürmann; Hans Preut; Hans-Dieter Arndt; Herbert Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-17       Impact factor: 11.205

9.  The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair.

Authors:  Sebastian Dworkin; Stephen M Jane; Charbel Darido
Journal:  Organogenesis       Date:  2011-07-01       Impact factor: 2.500

Review 10.  Cell polarity as a regulator of cancer cell behavior plasticity.

Authors:  Senthil K Muthuswamy; Bin Xue
Journal:  Annu Rev Cell Dev Biol       Date:  2012-08-06       Impact factor: 13.827
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