OBJECTIVES: To examine prevalence of low bone mineral density (BMD) among adults with disability, using World Health Organization diagnostic categories. DESIGN: Cross-sectional study. SETTING: National Rehabilitation Hospital, Dublin, Ireland. PARTICIPANTS: Patients (N=255; 178 men, 77 women) who were disabled for at least 3 months because of acquired brain injury, spinal cord injury, other neurologic condition, or lower-limb amputation. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Laboratory investigations including intact parathyroid hormone, 25-hydroxyvitamin D (25-OHD), and sex hormones; and BMD of lumbar spine and at least 1 hip, measured by dual-energy x-ray absorptiometry and expressed as T scores and z scores. RESULTS: Mean age +/- SD of participants was 48.7+/-15.6 years. Vitamin D deficiency, 25-OHD level 50 nmol/L or less, occurred in 154 (62.9%); insufficiency, a level between 51 and 72 nmol/L, occurred in 36 (14.7%). Based on T scores, 108 participants (42.4%) had osteopenia, and 60 (23.5%) had osteoporosis. A z score of -1 or less but more than -2 occurred in 76 (29.8%); a further 52 (20.4%) had a z score of -2 or less. On multiple linear regression analysis, ambulatory status and duration of disability were independent predictors of BMD at neck of femur (beta=.152, P=.007; beta=-.191, P=.001, respectively) and total proximal femur (beta=.170, P=.001; beta=-.216, P<.001, respectively). CONCLUSIONS: Osteopenia and osteoporosis are very common in adults with disability participating in rehabilitation, compared with the general young adult population. Duration since onset of disability and mobility status are independent predictors of BMD at the hip. Bone health monitoring should form part of the long-term follow-up in adults with newly acquired disabilities.
OBJECTIVES: To examine prevalence of low bone mineral density (BMD) among adults with disability, using World Health Organization diagnostic categories. DESIGN: Cross-sectional study. SETTING: National Rehabilitation Hospital, Dublin, Ireland. PARTICIPANTS: Patients (N=255; 178 men, 77 women) who were disabled for at least 3 months because of acquired brain injury, spinal cord injury, other neurologic condition, or lower-limb amputation. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Laboratory investigations including intact parathyroid hormone, 25-hydroxyvitamin D (25-OHD), and sex hormones; and BMD of lumbar spine and at least 1 hip, measured by dual-energy x-ray absorptiometry and expressed as T scores and z scores. RESULTS: Mean age +/- SD of participants was 48.7+/-15.6 years. Vitamin D deficiency, 25-OHD level 50 nmol/L or less, occurred in 154 (62.9%); insufficiency, a level between 51 and 72 nmol/L, occurred in 36 (14.7%). Based on T scores, 108 participants (42.4%) had osteopenia, and 60 (23.5%) had osteoporosis. A z score of -1 or less but more than -2 occurred in 76 (29.8%); a further 52 (20.4%) had a z score of -2 or less. On multiple linear regression analysis, ambulatory status and duration of disability were independent predictors of BMD at neck of femur (beta=.152, P=.007; beta=-.191, P=.001, respectively) and total proximal femur (beta=.170, P=.001; beta=-.216, P<.001, respectively). CONCLUSIONS:Osteopenia and osteoporosis are very common in adults with disability participating in rehabilitation, compared with the general young adult population. Duration since onset of disability and mobility status are independent predictors of BMD at the hip. Bone health monitoring should form part of the long-term follow-up in adults with newly acquired disabilities.
Authors: Andreas Eigentler; Wolfgang Nachbauer; Eveline Donnemiller; Werner Poewe; Rudolf W Gasser; Sylvia Boesch Journal: Cerebellum Date: 2014-10 Impact factor: 3.847
Authors: William A Bauman; Racine R Emmons; Christopher M Cirnigliaro; Steven C Kirshblum; Ann M Spungen Journal: J Spinal Cord Med Date: 2011 Impact factor: 1.985
Authors: Samuel Amorim; Vitor Hugo Teixeira; Rui Corredeira; Maria Cunha; Bruno Maia; Paulo Margalho; Joana Pires Journal: J Spinal Cord Med Date: 2017-09-13 Impact factor: 1.985
Authors: R D Brady; B L Grills; T Romano; J D Wark; T J O'Brien; S R Shultz; S J McDonald Journal: J Musculoskelet Neuronal Interact Date: 2016-12-14 Impact factor: 2.041
Authors: Rhys D Brady; Brian L Grills; Jarrod E Church; Nicole C Walsh; Aaron C McDonald; Denes V Agoston; Mujun Sun; Terence J O'Brien; Sandy R Shultz; Stuart J McDonald Journal: Sci Rep Date: 2016-09-29 Impact factor: 4.379