Literature DB >> 19576917

3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica.

Abdel-Hamid A Hamdy1, Elsayed A Aboutabl, Somayah Sameer, Ahmed A Hussein, Ana R Díaz-Marrero, José Darias, Mercedes Cueto.   

Abstract

Bioassay-guided purification of an ethanolic extract of Cystoseira myrica against HEPG-2 (liver) and HCT116 (colon) human cancer cell lines led to the isolation of 3-keto-22-epi-28-nor-cathasterone, 1 and cholest-4-ene-3,6-dione, 2. This finding allowed us to report for the first time that a brassinosteroid-related metabolite occurs in seaweed. These compounds showed activity in the range of 12.38-1.16 microM with selective activity of compound 2 to liver cancer cell lines.

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Year:  2009        PMID： 19576917     DOI： 10.1016/j.steroids.2009.06.008

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  3 in total

1.  Semi-Quantitative Targeted Gas Chromatography-Mass Spectrometry Profiling Supports a Late Side-Chain Reductase Cycloartenol-to-Cholesterol Biosynthesis Pathway in Brown Algae.

Authors:  Jean Girard; Goulven Lanneau; Ludovic Delage; Cédric Leroux; Arnaud Belcour; Jeanne Got; Jonas Collén; Catherine Boyen; Anne Siegel; Simon M Dittami; Catherine Leblanc; Gabriel V Markov
Journal:  Front Plant Sci       Date:  2021-04-27       Impact factor: 5.753

2.  24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP-Induced Oxidative Stress and Apoptosis.

Authors:  Julie Carange; Fanny Longpré; Benoit Daoust; Maria-Grazia Martinoli
Journal:  J Toxicol       Date:  2011-06-03

3.  Disulfated Ophiuroid Type Steroids from the Far Eastern Starfish Pteraster marsippus and Their Cytotoxic Activity on the Models of 2D and 3D Cultures.

Authors:  Alla A Kicha; Anatoly I Kalinovsky; Timofey V Malyarenko; Olesya S Malyarenko; Svetlana P Ermakova; Roman S Popov; Valentin A Stonik; Natalia V Ivanchina
Journal:  Mar Drugs       Date:  2022-02-24       Impact factor: 5.118
  3 in total

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