| Literature DB >> 19576765 |
Fredrik Wångsell1, Francesco Russo, Jonas Sävmarker, Asa Rosenquist, Bertil Samuelsson, Mats Larhed.
Abstract
Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC(50) value of 0.23 microM.Entities:
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Year: 2009 PMID： 19576765 DOI： 10.1016/j.bmcl.2009.06.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823