| Literature DB >> 19576171 |
Shintarou Kimura1, Eiji Warabi, Toru Yanagawa, Dongmei Ma, Ken Itoh, Yoshiyuki Ishii, Yasuhiro Kawachi, Tetsuro Ishii.
Abstract
Much of the cell injury caused by ultraviolet A (UVA) irradiation is associated with oxidative stress. Quercetin is a major natural polyphenol that is known to protect cells from UVA-induced damage. Here, we investigated the molecular mechanism of this protection. Quercetin pretreatment strongly suppressed UVA-induced apoptosis in human keratinocyte HaCaT cells, markedly increased protein levels of the transcription factor Nrf2, induced the expression of antioxidative genes, and dramatically reduced the production of reactive oxygen species following UVA irradiation. Importantly, these beneficial effects were greatly attenuated by downregulating Nrf2 expression. Thus, quercetin protects cells from UVA damage mainly by elevating intracellular antioxidative activity via the enhanced accumulation of a transcription factor for antioxidant genes, Nrf2.Entities:
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Year: 2009 PMID： 19576171 DOI： 10.1016/j.bbrc.2009.06.136
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575