AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.
AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.
Authors: F de la Portilla; J J Segura-Sampedro; M L Reyes-Díaz; M V Maestre; A M Cabrera; R M Jimenez-Rodríguez; J M Vázquez-Monchul; J M Diaz-Pavón; F J Padillo-Ruiz Journal: Int J Colorectal Dis Date: 2017-07-29 Impact factor: 2.571
Authors: Andreas Ommer; Alexander Herold; Eugen Berg; Alois Fürst; Stefan Post; Reinhard Ruppert; Thomas Schiedeck; Oliver Schwandner; Bernhard Strittmatter Journal: Langenbecks Arch Surg Date: 2017-03-01 Impact factor: 3.445
Authors: R S van Onkelen; M P Gosselink; M van Meurs; M J Melief; W R Schouten; J D Laman Journal: Tech Coloproctol Date: 2016-07-11 Impact factor: 3.781