Kamaljeet Singh1. 1. Department of Pathology, Rhode Island Hospital and Miriam Hospital, Providence, RI 02903, USA. kamallabana@rediffmail.com
Abstract
PURPOSE: To report an ultrastructurally distinct form of paraprotein crystalline keratopathy. METHODS: Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed. RESULTS: The transmission electron microscopy showed "immunotactoid" extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core. CONCLUSIONS: Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.
PURPOSE: To report an ultrastructurally distinct form of paraprotein crystalline keratopathy. METHODS: Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed. RESULTS: The transmission electron microscopy showed "immunotactoid" extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core. CONCLUSIONS: Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.
Authors: Walter Lisch; Joanna Wasielica-Poslednik; Tero Kivelä; Ursula Schlötzer-Schrehardt; Jens M Rohrbach; Walter Sekundo; Uwe Pleyer; Christina Lisch; Alexander Desuki; Heidi Rossmann; Jayne S Weiss Journal: Trans Am Ophthalmol Soc Date: 2016-08
Authors: Kitti Kormányos; Klaudia Kovács; Orsolya Németh; Gábor Tóth; Gábor László Sándor; Anita Csorba; Cecília Nóra Czakó; László Módis; Achim Langenbucher; Zoltán Zsolt Nagy; Gergely Varga; László Gopcsa; Gábor Mikala; Nóra Szentmáry Journal: J Clin Med Date: 2022-03-26 Impact factor: 4.241