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Literature DB >> 19574199

Wnt signalling and cancer stem cells.

Jesús Espada¹, Moisés B Calvo, Silvia Díaz-Prado, Vanessa Medina.

Abstract

Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefl y reviewed.

Entities: Disease

Mesh：

Substances：
Wnt Proteins

Year: 2009 PMID： 19574199 DOI： 10.1007/s12094-009-0380-4

Source DB: PubMed Journal: Clin Transl Oncol ISSN： 1699-048X Impact factor: 3.405

133 in total

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