Literature DB >> 19574045

Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.

David Elliot1, Eleanor Henshaw, Philip A MacFaul, Andrew D Morley, Peter Newham, Keith Oldham, Ken Page, Neil Rankine, Paul Sharpe, Attilla Ting, Christine M Wood.   

Abstract

A novel approach to inhibition of the alphavbeta3 integrin is described, which uses compounds designed to generate nM potency without using the arginine binding site.

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Year:  2009        PMID： 19574045     DOI： 10.1016/j.bmcl.2009.06.041

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Correlation between biological activity and binding energy in systems of integrin with cyclic RGD-containing binders: a QM/MM molecular dynamics study.

Authors:  Mingli Xiang; Yuchun Lin; Gu He; Lijuan Chen; Mingli Yang; Shengyong Yang; Yirong Mo
Journal:  J Mol Model       Date:  2012-06-27       Impact factor: 1.810

2.  Small molecule inhibitors of hantavirus infection.

Authors:  Pamela R Hall; Andrei Leitão; Chunyan Ye; Kathleen Kilpatrick; Brian Hjelle; Tudor I Oprea; Richard S Larson
Journal:  Bioorg Med Chem Lett       Date:  2010-09-19       Impact factor: 2.823
  2 in total

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