Literature DB >> 19574010

Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement.

Lin Li1, Min-Yong Low, Xiaowei Ge, Bosco C Bloodworth, Hwee-Ling Koh.   

Abstract

A health supplement used for sexual performance enhancement was sent to Health Sciences Authority of Singapore for testing. An unknown compound was detected and isolated and its structure was elucidated using NMR, high-resolution MS, ESI-MS/MS, UV and IR. The compound, dapoxetine, is reported to be a selective serotonin reuptake inhibitor under investigation for the treatment of premature ejaculation.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19574010     DOI: 10.1016/j.jpba.2009.06.005

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN: 0731-7085            Impact factor:   3.935


  4 in total

1.  Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations.

Authors:  Ali Kamal Attia; Eglal R Souaya; Ethar A Soliman
Journal:  Adv Pharm Bull       Date:  2015-11-30

2.  Advances in structure elucidation of small molecules using mass spectrometry.

Authors:  Tobias Kind; Oliver Fiehn
Journal:  Bioanal Rev       Date:  2010-08-21

3.  Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium-Gold Nanoparticles.

Authors:  Mona A Mohamed; Shimaa A Atty; Ali M Yehia; Christopher W Foster; Craig E Banks; Nageh K Allam
Journal:  ACS Omega       Date:  2017-10-11

4.  Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique.

Authors:  Mona N Abou-Omar; Abdelaziz M Annadi; Noha M El Zahar; Ahmed O Youssef; Mohammed A Amin; Mohamed S Attia; Ekram H Mohamed
Journal:  RSC Adv       Date:  2021-09-06       Impact factor: 4.036

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.