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Literature DB >> 19573617

Role of Nod2 in the development of Crohn's disease.

Abstract

Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2009 PMID： 19573617 PMCID： PMC2924159 DOI： 10.1016/j.micinf.2009.06.005

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

50 in total

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9. NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease.

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5. Role of NOD2 in regulating the immune response to Aspergillus fumigatus.

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Review 6. Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease.

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