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Literature DB >> 19573532

Osteopontin: role in extracellular matrix deposition and myocardial remodeling post-MI.

Mahipal Singh¹, Cerrone R Foster, Suman Dalal, Krishna Singh.

Abstract

Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and improved LV function in mice lacking OPN after MI. This review summarizes--1) signaling pathways leading to increased expression of OPN in the heart; 2) the alterations in the structure and function of the heart post-MI in mice lacking OPN; and 3) mechanisms involved in OPN-mediated ECM remodeling post-MI. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Osteopontin

Year: 2009 PMID： 19573532 PMCID： PMC2823840 DOI： 10.1016/j.yjmcc.2009.06.015

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

50 in total

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Journal: Circulation Date: 1997-11-04 Impact factor: 29.690

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Journal: Circ Res Date: 1994-02 Impact factor: 17.367

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Journal: Circulation Date: 1998-07-14 Impact factor: 29.690

45 in total

1. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.

Authors: Andriy Yabluchanskiy; Yonggang Ma; Kristine Y DeLeon-Pennell; Raffaele Altara; Ganesh V Halade; Andrew P Voorhees; Nguyen T Nguyen; Yu-Fang Jin; Michael D Winniford; Michael E Hall; Hai-Chao Han; Merry L Lindsey
Journal: J Gerontol A Biol Sci Med Sci Date: 2015-04-15 Impact factor: 6.053

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Authors: Nikolaos G Frangogiannis
Journal: Physiol Rev Date: 2012-04 Impact factor: 37.312

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Authors: Yutaka Matsui; Junko Morimoto; Toshimitsu Uede
Journal: World J Biol Chem Date: 2010-05-26

4. Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure.

Authors: Michael R Zile; Stacia M Desantis; Catalin F Baicu; Robert E Stroud; Sheila B Thompson; Catherine D McClure; Shannon M Mehurg; Francis G Spinale
Journal: Circ Heart Fail Date: 2011-02-24 Impact factor: 8.790

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Authors: Merry L Lindsey; Fouad A Zouein; Yuan Tian; Rugmani Padmanabhan Iyer; Lisandra E de Castro Brás
Journal: Can J Physiol Pharmacol Date: 2015-03-26 Impact factor: 2.273

6. Elevated expression of activated Na(+)/H(+) exchanger protein induces hypertrophy in isolated rat neonatal ventricular cardiomyocytes.

Authors: Fatima Mraiche; Larry Fliegel
Journal: Mol Cell Biochem Date: 2011-07-01 Impact factor: 3.396