Literature DB >> 1957350

Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition.

J W Schwabe1, D Rhodes.   

Abstract

The highly conserved DNA-binding domain of the steroid hormone receptors contains two 'zinc finger'-like sequence motifs. The three-dimensional structure in solution has been determined using two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy and shows that the two 'zinc finger'-like motifs fold to form a single structural domain. The combination of this structural information and mutagenesis data reveals how this family of transcriptional regulators bind to DNA.

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Year:  1991        PMID： 1957350     DOI： 10.1016/0968-0004(91)90121-b

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  24 in total

1.  Identification and preliminary characterization of a protein motif related to the zinc finger.

Authors:  R Lovering; I M Hanson; K L Borden; S Martin; N J O'Reilly; G I Evan; D Rahman; D J Pappin; J Trowsdale; P S Freemont
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

2.  Cloning and characterization of ribosomal protein S29, a deltamethrin resistance associated gene from Culex pipiens pallens.

Authors:  Haibo Sun; Linchun Sun; Ji He; Bo Shen; Jing Yu; Chen Chen; Mifang Yang; Yan Sun; Donghui Zhang; Lei Ma; Changliang Zhu
Journal:  Parasitol Res       Date:  2011-05-12       Impact factor: 2.289

3.  A novel protein with DNA binding activity from tobacco chloroplast nucleoids.

Authors:  T Nakano; S Murakami; T Shoji; S Yoshida; Y Yamada; F Sato
Journal:  Plant Cell       Date:  1997-09       Impact factor: 11.277

4.  FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs.

Authors:  C J Schwartz; H M Sampson; D Hlousek; A Percival-Smith; J W Copeland; A J Simmonds; H M Krause
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

5.  Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.

Authors:  Alesia N McKeown; Jamie T Bridgham; Dave W Anderson; Michael N Murphy; Eric A Ortlund; Joseph W Thornton
Journal:  Cell       Date:  2014-09-25       Impact factor: 41.582

6.  Oral zinc augmentation with vitamins A and D increases plasma zinc concentration: implications for burden of disease.

Authors:  F C V Potocnik; S J van Rensburg; D Hon; R A Emsley; I M Moodie; R T Erasmus
Journal:  Metab Brain Dis       Date:  2006-08-02       Impact factor: 3.584

7.  Baculovirus gene ME53, which contains a putative zinc finger motif, is one of the major early-transcribed genes.

Authors:  D Knebel-Mörsdorf; A Kremer; F Jahnel
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

8.  Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.

Authors:  N C Vamvakopoulos; G P Chrousos
Journal:  J Clin Invest       Date:  1993-10       Impact factor: 14.808

9.  The DNA binding domains of the yeast Gal4 and human c-Jun transcription factors interact through the zinc-finger and bZIP motifs.

Authors:  K Sollerbrant; G Akusjärvi; S Linder; C Svensson
Journal:  Nucleic Acids Res       Date:  1995-02-25       Impact factor: 16.971

10.  Mutation analysis of the Cys-X2-Cys-X19-Cys-X2-Cys motif in the beta subunit of eukaryotic translation initiation factor 2.

Authors:  B Castilho-Valavicius; G M Thompson; T F Donahue
Journal:  Gene Expr       Date:  1992
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