| Literature DB >> 19572613 |
Yonggang Zhang1, Shunchun Liu, Hongwei Liu, Xingzhong Liu, Yongsheng Che.
Abstract
Cycloaspeptides F (1) and G (2), two new cyclic pentapeptides, and the known cycloaspeptides A (3), C (4), and bisdethiodi(methylthio)hyalodendrin (5) have been isolated from the crude extract of the fungus Isaria farinosa that colonizes Cordyceps sinensis. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method on its acid hydrolysate. Compounds 1 and 2 showed cytotoxic effects against HeLa and MCF7 cell lines, displaying the same magnitude of activity toward the MCF7 cells as the positive control 5-fluorouracil.Entities:
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Year: 2009 PMID： 19572613 DOI： 10.1021/np900205m
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050