| Literature DB >> 19572611 |
Feng Li1, Suresh Awale, Hongyan Zhang, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota.
Abstract
A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC(50) value of 9.3 microg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3-13) and four known prenylated flavanones (14-17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC(50) 4.3 microM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19572611 DOI： 10.1021/np9002433
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050