Literature DB >> 19572212

Gene expression profiles in the prefrontal cortex of SHR rats by cDNA microarrays.

Jie Qiu1, Qin Hong, Rong-hua Chen, Mei-ling Tong, Min Zhang, Li Fei, Xiao-qin Pan, Mei Guo, Xi-rong Guo, Xia Chi.   

Abstract

We have undertaken cDNA microarrays to identify differentially expressed genes in the prefrontal cortex (PFC) of spontaneously hypertensive-rat (SHR), a rodent model of attention deficit hyperactivity disorder (ADHD) versus control Wistar-Kyoto (WKY) rats. The analysis of the gene expression profiles indicated that 57 genes were up-regulated and 97 genes were down-regulated in the PFC of SHR. These predominately expressed genes included genes involved in neural development, immunity, transcription factor, monoamine neurotransmitter, metabolism, signal transduction, apoptosis and so on. Although more detailed analyses are necessary, it is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of ADHD.

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Year:  2009        PMID： 19572212     DOI： 10.1007/s11033-009-9596-1

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  48 in total

1.  Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration.

Authors:  Elena Castro; Rosa M Tordera; Zoe A Hughes; Qi Pei; Trevor Sharp
Journal:  J Neurochem       Date:  2003-06       Impact factor: 5.372

Review 2.  Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes.

Authors:  F Xavier Castellanos; Rosemary Tannock
Journal:  Nat Rev Neurosci       Date:  2002-08       Impact factor: 34.870

3.  Development of a strain of spontaneously hypertensive rats.

Authors:  K OKAMOTO; K AOKI
Journal:  Jpn Circ J       Date:  1963-03

4.  In vivo regulation of Homer1a expression in the striatum by cocaine.

Authors:  Guo-Chi Zhang; Li-Min Mao; Xian-Yu Liu; Nikhil K Parelkar; Anish Arora; Lu Yang; Michelle Hains; Eugene E Fibuch; John Q Wang
Journal:  Mol Pharmacol       Date:  2007-01-18       Impact factor: 4.436

5.  Homer2 is necessary for EtOH-induced neuroplasticity.

Authors:  Karen K Szumlinski; Kevin D Lominac; Erik B Oleson; Jennifer K Walker; Ashley Mason; Marlin H Dehoff; Matthias Klugmann; Matthias Klugman; Stephanie Cagle; Kristine Welt; Matthew During; Paul F Worley; Lawrence D Middaugh; Peter W Kalivas
Journal:  J Neurosci       Date:  2005-07-27       Impact factor: 6.167

Review 6.  Attention-deficit/hyperactivity disorder endophenotypes.

Authors:  Alysa E Doyle; Erik G Willcutt; Larry J Seidman; Joseph Biederman; Virginie-Anne Chouinard; Julie Silva; Stephen V Faraone
Journal:  Biol Psychiatry       Date:  2005-06-01       Impact factor: 13.382

Review 7.  Attention-deficit hyperactivity disorder.

Authors:  Joseph Biederman; Stephen V Faraone
Journal:  Lancet       Date:  2005 Jul 16-22       Impact factor: 79.321

Review 8.  Molecular genetic studies of ADHD: 1991 to 2004.

Authors:  Aaron J Bobb; F Xavier Castellanos; Anjene M Addington; Judith L Rapoport
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2005-01-05       Impact factor: 3.568

9.  Dopamine transporter density in patients with attention deficit hyperactivity disorder.

Authors:  D D Dougherty; A A Bonab; T J Spencer; S L Rauch; B K Madras; A J Fischman
Journal:  Lancet       Date:  1999 Dec 18-25       Impact factor: 79.321

10.  Rapid detection of apoptosis through real-time reverse transcriptase polymerase chain reaction measurement of the small cytoplasmic RNA Y1.

Authors:  Fred A M Asselbergs; Roland Widmer
Journal:  Anal Biochem       Date:  2003-07-15       Impact factor: 3.365
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  9 in total

Review 1.  Glutamate receptors and signal transduction in learning and memory.

Authors:  Sheng Peng; Yan Zhang; Jiannan Zhang; Hua Wang; Bingxu Ren
Journal:  Mol Biol Rep       Date:  2010-04-03       Impact factor: 2.316

2.  MicroRNAs: a light into the "black box" of neuropediatric diseases?

Authors:  Ahmed Omran; Dalia Elimam; Sherien Shalaby; Jing Peng; Fei Yin
Journal:  Neuromolecular Med       Date:  2012-07-19       Impact factor: 3.843

3.  Animal models of stroke: translational potential at present and in 2050.

Authors:  Paco S Herson; Richard J Traystman
Journal:  Future Neurol       Date:  2014-09

4.  Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.

Authors:  Lara Ianov; Asha Rani; Blanca S Beas; Ashok Kumar; Thomas C Foster
Journal:  Front Aging Neurosci       Date:  2016-05-17       Impact factor: 5.750

5.  Effectiveness of methylphenidate and PUFA for the treatment of patients with ADHD: A double-blinded randomized clinical trial.

Authors:  Mahbobeh Firouzkouhi Moghaddam; Maryam Shamekhi; Tayebeh Rakhshani
Journal:  Electron Physician       Date:  2017-05-25

6.  Increased locomotor activity and non-selective attention and impaired learning ability in SD rats after lentiviral vector-mediated RNA interference of Homer 1a in the brain.

Authors:  Qin Hong; Lei Yang; Min Zhang; Xiao-Qin Pan; Mei Guo; Li Fei; Mei-Ling Tong; Rong-Hua Chen; Xi-Rong Guo; Xia Chi
Journal:  Int J Med Sci       Date:  2012-12-27       Impact factor: 3.738

7.  Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD).

Authors:  Ike dela Peña; Hee Jin Kim; Aeree Sohn; Bung-Nyun Kim; Doug Hyun Han; Jong Hoon Ryu; Chan Young Shin; Minsoo Noh; Jae Hoon Cheong
Journal:  Behav Brain Funct       Date:  2014-05-06       Impact factor: 3.759

8.  Nr3C1-Bhlhb2 Axis Dysregulation Is Involved in the Development of Attention Deficit Hyperactivity.

Authors:  Li Hui Wu; Wei Cheng; Mei Yu; Bao Mei He; Hui Sun; Qi Chen; Yi Wei Dong; Xiao Ting Shao; Qian Qian Cai; Min Peng; Xing Zhong Wu
Journal:  Mol Neurobiol       Date:  2016-01-28       Impact factor: 5.590

9.  Neurobiological Insights Into Stress-Induced Attention Deficit.

Authors:  Emily C Wright
Journal:  Biol Psychiatry       Date:  2020-10-01       Impact factor: 13.382
  9 in total

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