Literature DB >> 19571599

Evaluating quality in clinical cancer research: the M.D. Anderson Cancer Center experience.

James D Cox1, Sergio A Giralt, Mary L Veazie, Jaffer A Ajani, Janet M Bruner, Ka Wah Chan, Walter N Hittelman, Kelly K Hunt, Revathy B Iyer, Daniel D Karp, Deborah A Kuban, Scott M Lippman, Issam I Raad, Miguel A Rodriguez-Bigas, Leonard A Zwelling, Maurie Markman.   

Abstract

BACKGROUND: Despite the unquestionable importance of clinically oriented research designed to test the safety and efficacy of new therapies in patients with malignant disease, there is limited information regarding strategies to evaluate the quality of such efforts at academic institutions.
METHODS: To address this issue, a committee of senior faculty at the University of Texas M.D. Anderson Cancer Center established specific criteria by which investigators from all departments engaged in clinical research could be formally evaluated. Scoring criteria were established and revised based on the results of a pilot study. Beginning in January 2004, the committee evaluated all faculty involved in clinical research within 35 departments. Scores for individual faculty members were assigned on a scale of 1 (outstanding) to 5; a score of 3 was set as the standard for the institution. Each department also received a score. The results of the evaluation were shared with departmental chairs and the Chief Academic Officer.
RESULTS: 392 faculty were evaluated. The median score was 3. Full professors more frequently received a score of 1, but all faculty ranks received scores of 4 and 5. As a group, tenure/tenure track faculty achieved superior scores compared to nontenure track faculty.
CONCLUSIONS: Based on our experience, we believe it is possible to conduct a rigorous consensus-based evaluation of the quality of clinical cancer research being conducted at an academic medical center. It is reasonable to suggest such evaluations can be used as a management tool and may lead to higher-quality clinical research. Copyright 2009 S. Karger AG, Basel.

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Mesh:

Year:  2009        PMID: 19571599      PMCID: PMC2790774          DOI: 10.1159/000226772

Source DB:  PubMed          Journal:  Oncology        ISSN: 0030-2414            Impact factor:   2.935


  9 in total

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Authors:  T Bodenheimer
Journal:  N Engl J Med       Date:  2000-05-18       Impact factor: 91.245

2.  What makes clinical research ethical?

Authors:  E J Emanuel; D Wendler; C Grady
Journal:  JAMA       Date:  2000 May 24-31       Impact factor: 56.272

3.  Role of a research ethics committee in follow-up and publication of results.

Authors:  Judit Pich; Xavier Carné; Joan-Albert Arnaiz; Begoña Gómez; Antoni Trilla; Juan Rodés
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4.  Factors associated with failure to publish large randomized trials presented at an oncology meeting.

Authors:  Monika K Krzyzanowska; Melania Pintilie; Ian F Tannock
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5.  Subsequent publication of orally presented original studies within 5 years after 1995 RSNA Scientific Assembly.

Authors:  Lionel Arrivé; Pierre-Yves Boelle; Pascale Dono; Maïté Lewin; Laurence Monnier-Cholley; Jean-Michel Tubiana
Journal:  Radiology       Date:  2004-05-27       Impact factor: 11.105

6.  The Swedish Council on Technology Assessment in Health Care (SBU) report on Cancer Chemotherapy--Project objectives, the working process, key definitions and general aspects on cancer trial methodology and interpretation.

Authors:  P Nygren; B Glimelius
Journal:  Acta Oncol       Date:  2001       Impact factor: 4.089

7.  Full publication of results initially presented in abstracts. A meta-analysis.

Authors:  R W Scherer; K Dickersin; P Langenberg
Journal:  JAMA       Date:  1994-07-13       Impact factor: 56.272

8.  Evidence in oncology. The Janeway lecture 2000.

Authors:  J D Cox
Journal:  Cancer J       Date:  2000 Nov-Dec       Impact factor: 3.360

9.  Status of clinical research in academic health centers: views from the research leadership.

Authors:  E G Campbell; J S Weissman; E Moy; D Blumenthal
Journal:  JAMA       Date:  2001-08-15       Impact factor: 56.272

  9 in total

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