OBJECTIVES: Previously, a genome-wide scan has identified a nonsynonymous single nucleotide polymorphism (rs3812316, G771C, Gln241His) in the MLXIPL gene that is associated with the level of plasma triglycerides. However, no data are available on the association of this polymorphism with coronary artery disease (CAD) in the Chinese population. The aim of this study was to evaluate the association between a gene polymorphism related to triglyceride metabolism and CAD. METHODS: The genotype of the polymorphism in the MLXIPL gene was determined in 352 CAD patients and 152 CAD-free subjects. All of the participants were selected to study the MLXIPL gene rs3812316 polymorphism using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: In Chinese participants, we observed that there was a significant difference in genotype between the cases and controls (p = 0.002). After allowance for potential confounders, unconditional logistic analysis revealed that the SNP was significantly related to a risk in CAD patients (adjusted OR 2.96, 95% CI 1.30-5.08; p =0.004). We also found that there was a significant association between the single nucleotide polymorphism and plasma triglyceride levels (OR 1.28, 95% CI 1.061-1.542; p < 0.05). CONCLUSION: The gene sequence variation in the MLXIPL gene may serve as a novel genetic marker for the risk of significant CAD. Copyright 2009 S. Karger AG, Basel.
OBJECTIVES: Previously, a genome-wide scan has identified a nonsynonymous single nucleotide polymorphism (rs3812316, G771C, Gln241His) in the MLXIPL gene that is associated with the level of plasma triglycerides. However, no data are available on the association of this polymorphism with coronary artery disease (CAD) in the Chinese population. The aim of this study was to evaluate the association between a gene polymorphism related to triglyceride metabolism and CAD. METHODS: The genotype of the polymorphism in the MLXIPL gene was determined in 352 CAD patients and 152 CAD-free subjects. All of the participants were selected to study the MLXIPL gene rs3812316 polymorphism using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: In Chinese participants, we observed that there was a significant difference in genotype between the cases and controls (p = 0.002). After allowance for potential confounders, unconditional logistic analysis revealed that the SNP was significantly related to a risk in CAD patients (adjusted OR 2.96, 95% CI 1.30-5.08; p =0.004). We also found that there was a significant association between the single nucleotide polymorphism and plasma triglyceride levels (OR 1.28, 95% CI 1.061-1.542; p < 0.05). CONCLUSION: The gene sequence variation in the MLXIPL gene may serve as a novel genetic marker for the risk of significant CAD. Copyright 2009 S. Karger AG, Basel.
Authors: Anne E Justice; Tugce Karaderi; Heather M Highland; Kristin L Young; Mariaelisa Graff; Yingchang Lu; Valérie Turcot; L Adrienne Cupples; Ruth J F Loos; Kari E North; Cecilia M Lindgren; Paul L Auer; Rebecca S Fine; Xiuqing Guo; Claudia Schurmann; Adelheid Lempradl; Eirini Marouli; Anubha Mahajan; Thomas W Winkler; Adam E Locke; Carolina Medina-Gomez; Tõnu Esko; Sailaja Vedantam; Ayush Giri; Ken Sin Lo; Tamuno Alfred; Poorva Mudgal; Maggie C Y Ng; Nancy L Heard-Costa; Mary F Feitosa; Alisa K Manning; Sara M Willems; Suthesh Sivapalaratnam; Goncalo Abecasis; Dewan S Alam; Matthew Allison; Philippe Amouyel; Zorayr Arzumanyan; Beverley Balkau; Lisa Bastarache; Sven Bergmann; Lawrence F Bielak; Matthias Blüher; Michael Boehnke; Heiner Boeing; Eric Boerwinkle; Carsten A Böger; Jette Bork-Jensen; Erwin P Bottinger; Donald W Bowden; Ivan Brandslund; Linda Broer; Amber A Burt; Adam S Butterworth; Mark J Caulfield; Giancarlo Cesana; John C Chambers; Daniel I Chasman; Yii-Der Ida Chen; Rajiv Chowdhury; Cramer Christensen; Audrey Y Chu; Francis S Collins; James P Cook; Amanda J Cox; David S Crosslin; John Danesh; Paul I W de Bakker; Simon de Denus; Renée de Mutsert; George Dedoussis; Ellen W Demerath; Joe G Dennis; Josh C Denny; Emanuele Di Angelantonio; Marcus Dörr; Fotios Drenos; Marie-Pierre Dubé; Alison M Dunning; Douglas F Easton; Paul Elliott; Evangelos Evangelou; Aliki-Eleni Farmaki; Shuang Feng; Ele Ferrannini; Jean Ferrieres; Jose C Florez; Myriam Fornage; Caroline S Fox; Paul W Franks; Nele Friedrich; Wei Gan; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Giorgia Girotto; Mathias Gorski; Harald Grallert; Niels Grarup; Megan L Grove; Stefan Gustafsson; Jeff Haessler; Torben Hansen; Andrew T Hattersley; Caroline Hayward; Iris M Heid; Oddgeir L Holmen; G Kees Hovingh; Joanna M M Howson; Yao Hu; Yi-Jen Hung; Kristian Hveem; M Arfan Ikram; Erik Ingelsson; Anne U Jackson; Gail P Jarvik; Yucheng Jia; Torben Jørgensen; Pekka Jousilahti; Johanne M Justesen; Bratati Kahali; Maria Karaleftheri; Sharon L R Kardia; Fredrik Karpe; Frank Kee; Hidetoshi Kitajima; Pirjo Komulainen; Jaspal S Kooner; Peter Kovacs; Bernhard K Krämer; Kari Kuulasmaa; Johanna Kuusisto; Markku Laakso; Timo A Lakka; David Lamparter; Leslie A Lange; Claudia Langenberg; Eric B Larson; Nanette R Lee; Wen-Jane Lee; Terho Lehtimäki; Cora E Lewis; Huaixing Li; Jin Li; Ruifang Li-Gao; Li-An Lin; Xu Lin; Lars Lind; Jaana Lindström; Allan Linneberg; Ching-Ti Liu; Dajiang J Liu; Jian'an Luan; Leo-Pekka Lyytikäinen; Stuart MacGregor; Reedik Mägi; Satu Männistö; Gaëlle Marenne; Jonathan Marten; Nicholas G D Masca; Mark I McCarthy; Karina Meidtner; Evelin Mihailov; Leena Moilanen; Marie Moitry; Dennis O Mook-Kanamori; Anna Morgan; Andrew P Morris; Martina Müller-Nurasyid; Patricia B Munroe; Narisu Narisu; Christopher P Nelson; Matt Neville; Ioanna Ntalla; Jeffrey R O'Connell; Katharine R Owen; Oluf Pedersen; Gina M Peloso; Craig E Pennell; Markus Perola; James A Perry; John R B Perry; Tune H Pers; Ailith Ewing; Ozren Polasek; Olli T Raitakari; Asif Rasheed; Chelsea K Raulerson; Rainer Rauramaa; Dermot F Reilly; Alex P Reiner; Paul M Ridker; Manuel A Rivas; Neil R Robertson; Antonietta Robino; Igor Rudan; Katherine S Ruth; Danish Saleheen; Veikko Salomaa; Nilesh J Samani; Pamela J Schreiner; Matthias B Schulze; Robert A Scott; Marcelo Segura-Lepe; Xueling Sim; Andrew J Slater; Kerrin S Small; Blair H Smith; Jennifer A Smith; Lorraine Southam; Timothy D Spector; Elizabeth K Speliotes; Kari Stefansson; Valgerdur Steinthorsdottir; Kathleen E Stirrups; Konstantin Strauch; Heather M Stringham; Michael Stumvoll; Liang Sun; Praveen Surendran; Karin M A Swart; Jean-Claude Tardif; Kent D Taylor; Alexander Teumer; Deborah J Thompson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Betina H Thuesen; Anke Tönjes; Mina Torres; Emmanouil Tsafantakis; Jaakko Tuomilehto; André G Uitterlinden; Matti Uusitupa; Cornelia M van Duijn; Mauno Vanhala; Rohit Varma; Sita H Vermeulen; Henrik Vestergaard; Veronique Vitart; Thomas F Vogt; Dragana Vuckovic; Lynne E Wagenknecht; Mark Walker; Lars Wallentin; Feijie Wang; Carol A Wang; Shuai Wang; Nicholas J Wareham; Helen R Warren; Dawn M Waterworth; Jennifer Wessel; Harvey D White; Cristen J Willer; James G Wilson; Andrew R Wood; Ying Wu; Hanieh Yaghootkar; Jie Yao; Laura M Yerges-Armstrong; Robin Young; Eleftheria Zeggini; Xiaowei Zhan; Weihua Zhang; Jing Hua Zhao; Wei Zhao; He Zheng; Wei Zhou; M Carola Zillikens; Fernando Rivadeneira; Ingrid B Borecki; J Andrew Pospisilik; Panos Deloukas; Timothy M Frayling; Guillaume Lettre; Karen L Mohlke; Jerome I Rotter; Zoltán Kutalik; Joel N Hirschhorn Journal: Nat Genet Date: 2019-02-18 Impact factor: 38.330