Literature DB >> 19571468

Application of genetically modified and cloned pigs in translational research.

Hitomi Matsunari1, Hiroshi Nagashima.   

Abstract

Pigs are increasingly being recognized as good large-animal models for translational research, linking basic science to clinical applications in order to establish novel therapeutics. This article reviews the current status and future prospects of genetically modified and cloned pigs in translational studies. It also highlights pigs specially designed as disease models, for xenotransplantation or to carry cell marker genes. Finally, use of porcine somatic stem and progenitor cells in preclinical studies of cell transplantation therapy is also discussed.

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Year:  2009        PMID： 19571468     DOI： 10.1262/jrd.20164

Source DB:  PubMed          Journal:  J Reprod Dev        ISSN： 0916-8818            Impact factor:   2.214


  13 in total

Review 1.  Transgenic pigs as models for translational biomedical research.

Authors:  Bernhard Aigner; Simone Renner; Barbara Kessler; Nikolai Klymiuk; Mayuko Kurome; Annegret Wünsch; Eckhard Wolf
Journal:  J Mol Med (Berl)       Date:  2010-03-26       Impact factor: 4.599

Review 2.  The presence, role and clinical use of spermatozoal RNAs.

Authors:  Meritxell Jodar; Sellappan Selvaraju; Edward Sendler; Michael P Diamond; Stephen A Krawetz
Journal:  Hum Reprod Update       Date:  2013-07-14       Impact factor: 15.610

3.  Generation of heterozygous PKD1 mutant pigs exhibiting early-onset renal cyst formation.

Authors:  Masahito Watanabe; Kazuhiro Umeyama; Kazuaki Nakano; Hitomi Matsunari; Toru Fukuda; Kei Matsumoto; Susumu Tajiri; Shuichiro Yamanaka; Koki Hasegawa; Kazutoshi Okamoto; Ayuko Uchikura; Shuko Takayanagi; Masaki Nagaya; Takashi Yokoo; Hiromitsu Nakauchi; Hiroshi Nagashima
Journal:  Lab Invest       Date:  2022-01-03       Impact factor: 5.502

4.  Production of transgenic cloned pigs expressing the far-red fluorescent protein monomeric Plum.

Authors:  Masahito Watanabe; Mirina Kobayashi; Masaki Nagaya; Hitomi Matsunari; Kazuaki Nakano; Miki Maehara; Gota Hayashida; Shuko Takayanagi; Rieko Sakai; Kazuhiro Umeyama; Nobuyuki Watanabe; Masafumi Onodera; Hiroshi Nagashima
Journal:  J Reprod Dev       Date:  2015-03-20       Impact factor: 2.214

5.  Generation of a miniature pig disease model for human Laron syndrome.

Authors:  Dan Cui; Fang Li; Qiuyan Li; Jia Li; Yaofeng Zhao; Xiaoxiang Hu; Ran Zhang; Ning Li
Journal:  Sci Rep       Date:  2015-10-29       Impact factor: 4.379

6.  Production of CMAH Knockout Preimplantation Embryos Derived From Immortalized Porcine Cells Via TALE Nucleases.

Authors:  JoonHo Moon; Choongil Lee; Su Jin Kim; Ji-Yei Choi; Byeong Chun Lee; Jin-Soo Kim; Goo Jang
Journal:  Mol Ther Nucleic Acids       Date:  2014-05-27       Impact factor: 10.183

7.  A transgenic-cloned pig model expressing non-fluorescent modified Plum.

Authors:  Masaki Nagaya; Masahito Watanabe; Mirina Kobayashi; Kazuaki Nakano; Yoshikazu Arai; Yoshinori Asano; Toki Takeishi; Ikuma Umeki; Tooru Fukuda; Sayaka Yashima; Shuko Takayanagi; Nobuyuki Watanabe; Masafumi Onodera; Hitomi Matsunari; Kazuhiro Umeyama; Hiroshi Nagashima
Journal:  J Reprod Dev       Date:  2016-07-11       Impact factor: 2.214

8.  Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.

Authors:  Shuji Miyagawa; Hitomi Matsunari; Masahito Watanabe; Kazuaki Nakano; Kazuhiro Umeyama; Rieko Sakai; Shuko Takayanagi; Toki Takeishi; Tooru Fukuda; Sayaka Yashima; Akira Maeda; Hiroshi Eguchi; Hiroomi Okuyama; Masaki Nagaya; Hiroshi Nagashima
Journal:  J Reprod Dev       Date:  2015-07-26       Impact factor: 2.214

9.  Generation of interleukin-2 receptor gamma gene knockout pigs from somatic cells genetically modified by zinc finger nuclease-encoding mRNA.

Authors:  Masahito Watanabe; Kazuaki Nakano; Hitomi Matsunari; Taisuke Matsuda; Miki Maehara; Takahiro Kanai; Mirina Kobayashi; Yukina Matsumura; Rieko Sakai; Momoko Kuramoto; Gota Hayashida; Yoshinori Asano; Shuko Takayanagi; Yoshikazu Arai; Kazuhiro Umeyama; Masaki Nagaya; Yutaka Hanazono; Hiroshi Nagashima
Journal:  PLoS One       Date:  2013-10-09       Impact factor: 3.240

Review 10.  Large animal models for stem cell therapy.

Authors:  John Harding; R Michael Roberts; Oleg Mirochnitchenko
Journal:  Stem Cell Res Ther       Date:  2013-03-28       Impact factor: 6.832
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