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Literature DB >> 19570667

Immunosenescence: what does it mean to health outcomes in older adults?

Abstract

The most profound consequences of immune senescence with respect to human health are the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes in both innate and adaptive immune function converge in the reduced response to vaccination and protection against infection and related diseases. The decline in thymic output of naïve T cells diminishes responses to novel antigens, such as West Nile Virus, while clonal expansions leading to defects in the T cell repertoire are associated with blunted responses of memory T cells to conserved epitopes of the influenza virus. Recent studies on how immunologic mechanisms of protection change during aging have led to novel strategies for improving vaccine responsiveness and outcomes of infectious diseases in older adults.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19570667 PMCID： PMC2725188 DOI： 10.1016/j.coi.2009.05.023

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

47 in total

Review 1. CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity.

Authors: R Cortesini; J LeMaoult; R Ciubotariu; N S Cortesini
Journal: Immunol Rev Date: 2001-08 Impact factor: 12.988

Review 2. The role of CD8+ T-cell replicative senescence in human aging.

Authors: Rita B Effros; Mirabelle Dagarag; Carolyn Spaulding; Janice Man
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

3. Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.

Authors: Giovanni Almanzar; Susanne Schwaiger; Brigitte Jenewein; Michael Keller; Dietmar Herndler-Brandstetter; Reinhard Würzner; Diether Schönitzer; Beatrix Grubeck-Loebenstein
Journal: J Virol Date: 2005-03 Impact factor: 5.103

4. Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization.

Authors: Mirabelle Dagarag; Tandik Evazyan; Nagesh Rao; Rita B Effros
Journal: J Immunol Date: 2004-11-15 Impact factor: 5.422

Review 5. Reversal of age-associated thymic atrophy: treatments, delivery, and side effects.

Authors: Richard Aspinall; Wayne Mitchell
Journal: Exp Gerontol Date: 2008-05-01 Impact factor: 4.032

6. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).

Authors: Qin Ouyang; Wolfgang M Wagner; David Voehringer; Anders Wikby; Tatjana Klatt; Steffen Walter; Claudia A Müller; Hanspeter Pircher; Graham Pawelec
Journal: Exp Gerontol Date: 2003-08 Impact factor: 4.032

7. Premature aging of T cells is associated with faster HIV-1 disease progression.

Authors: Weiwei Cao; Beth D Jamieson; Lance E Hultin; Patricia M Hultin; Rita B Effros; Roger Detels
Journal: J Acquir Immune Defic Syndr Date: 2009-02-01 Impact factor: 3.731

8. Rapid turnover of the CD8(+)CD28(-) T-cell subset of effector cells in the circulation of patients with head and neck cancer.

Authors: Takashi Tsukishiro; Albert D Donnenberg; Theresa L Whiteside
Journal: Cancer Immunol Immunother Date: 2003-06-19 Impact factor: 6.968

9. Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties.

Authors: Eric T Clambey; Janice White; John W Kappler; Philippa Marrack
Journal: Proc Natl Acad Sci U S A Date: 2008-08-26 Impact factor: 11.205

10. Age-associated change in the frequency of memory CD4+ T cells impairs long term CD4+ T cell responses to influenza vaccine.

Authors: Insoo Kang; Myung Sun Hong; Helena Nolasco; Sung Hwan Park; Jin Myung Dan; Jin-Young Choi; Joe Craft
Journal: J Immunol Date: 2004-07-01 Impact factor: 5.422

136 in total

1. Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses.

Authors: Raskit Lachmann; Martha Bajwa; Serena Vita; Helen Smith; Elizabeth Cheek; Arne Akbar; Florian Kern
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103

Review 2. Improving immunity in the elderly: current and future lessons from nonhuman primate models.

Authors: Christine Meyer; Amelia Kerns; Kristen Haberthur; Ilhem Messaoudi
Journal: Age (Dordr) Date: 2011-12-20

3. Mechanistic insights into the impairment of memory B cells and antibody production in the elderly.

Authors: Judith H Aberle; Karin Stiasny; Michael Kundi; Franz X Heinz
Journal: Age (Dordr) Date: 2012-01-27

4. Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine.

Authors: Daniela Frasca; Alain Diaz; Maria Romero; Mitch Phillips; Nicholas V Mendez; Ana Marie Landin; Bonnie B Blomberg
Journal: Int Immunol Date: 2012-01-25 Impact factor: 4.823

Review 5. Adoptive T-cell therapy using autologous tumor-infiltrating lymphocytes for metastatic melanoma: current status and future outlook.

Authors: Richard Wu; Marie-Andrée Forget; Jessica Chacon; Chantale Bernatchez; Cara Haymaker; Jie Qing Chen; Patrick Hwu; Laszlo G Radvanyi
Journal: Cancer J Date: 2012 Mar-Apr Impact factor: 3.360