OBJECTIVES: To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in children and its relationship to metabolic syndrome, insulin resistance, and waist circumference (WC). METHODS: This was a population-based cross-sectional, case-control study. Cases were selected among students of a primary and junior high school, respectively, and age- and sex-matched control subjects were selected randomly (ratio of cases to control subject was 37:113). RESULTS: Of the 846 students, aged between 6 and 15 years, enrolled in the study and screened by ultrasonography, 37 children were diagnosed as having NAFLD (score >/= 1). There was a significant sex difference in the prevalence of NAFLD(P = 0.003). The trend test revealed a strong dose-response relationship (P < 0.001) between pediatric NAFLD and the number of the proposed components of pediatric metabolic syndrome in Japan (MetS-JC), such as a clustering of the components of MetS-JC. Additionally, the linear trend of the odds ratios (ORs) with increasing percentile of the homeostasis model assessment-insulin resistance (HOMA-IR) was statistically significant (P < 0.001). However, when WC was added to the logistic model, the ORs were no longer significant, whereas WC turned out to be an independent risk factor for NAFLD regardless of the HOMA-IR index. CONCLUSION: The prevalence of NAFLD in children and adolescents is closely related to metabolic syndrome, insulin resistance, and WC.
OBJECTIVES: To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in children and its relationship to metabolic syndrome, insulin resistance, and waist circumference (WC). METHODS: This was a population-based cross-sectional, case-control study. Cases were selected among students of a primary and junior high school, respectively, and age- and sex-matched control subjects were selected randomly (ratio of cases to control subject was 37:113). RESULTS: Of the 846 students, aged between 6 and 15 years, enrolled in the study and screened by ultrasonography, 37 children were diagnosed as having NAFLD (score >/= 1). There was a significant sex difference in the prevalence of NAFLD(P = 0.003). The trend test revealed a strong dose-response relationship (P < 0.001) between pediatric NAFLD and the number of the proposed components of pediatric metabolic syndrome in Japan (MetS-JC), such as a clustering of the components of MetS-JC. Additionally, the linear trend of the odds ratios (ORs) with increasing percentile of the homeostasis model assessment-insulin resistance (HOMA-IR) was statistically significant (P < 0.001). However, when WC was added to the logistic model, the ORs were no longer significant, whereas WC turned out to be an independent risk factor for NAFLD regardless of the HOMA-IR index. CONCLUSION: The prevalence of NAFLD in children and adolescents is closely related to metabolic syndrome, insulin resistance, and WC.
Authors: P Colicchio; G Tarantino; F del Genio; P Sorrentino; G Saldalamacchia; C Finelli; P Conca; F Contaldo; F Pasanisi Journal: Ann Nutr Metab Date: 2005-08-02 Impact factor: 3.374
Authors: D F Y Chan; A M Li; W C W Chu; M H M Chan; E M C Wong; E K H Liu; I H S Chan; J Yin; C W K Lam; T F Fok; E A S Nelson Journal: Int J Obes Relat Metab Disord Date: 2004-10
Authors: Marta Rorat; Tomasz Jurek; Ernest Kuchar; Leszek Szenborn; Wojciech Golema; Agnieszka Halon Journal: World J Pediatr Date: 2012-12-29 Impact factor: 2.764