Literature DB >> 19566681

Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance.

Arno Wegkamp, Willem M de Vos, Eddy J Smid.   

Abstract

Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium.

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Year:  2009        PMID： 19566681     DOI： 10.1111/j.1574-6968.2009.01690.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  7 in total

1.  CRISPR/Cas9-Assisted Seamless Genome Editing in Lactobacillus plantarum and Its Application in N-Acetylglucosamine Production.

Authors:  Ding Zhou; Zhennan Jiang; Qingxiao Pang; Yuan Zhu; Qian Wang; Qingsheng Qi
Journal:  Appl Environ Microbiol       Date:  2019-10-16       Impact factor: 4.792

2.  Modulation of Lactobacillus plantarum gastrointestinal robustness by fermentation conditions enables identification of bacterial robustness markers.

Authors:  Hermien van Bokhorst-van de Veen; I-Chiao Lee; Maria L Marco; Michiel Wels; Peter A Bron; Michiel Kleerebezem
Journal:  PLoS One       Date:  2012-07-03       Impact factor: 3.240

3.  Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1.

Authors:  Arno Wegkamp; Astrid E Mars; Magda Faijes; Douwe Molenaar; Ric C H de Vos; Sebastian M J Klaus; Andrew D Hanson; Willem M de Vos; Eddy J Smid
Journal:  Microb Cell Fact       Date:  2010-12-17       Impact factor: 5.328

4.  High efficiency recombineering in lactic acid bacteria.

Authors:  Jan-Peter van Pijkeren; Robert A Britton
Journal:  Nucleic Acids Res       Date:  2012-02-10       Impact factor: 16.971

5.  Streptococcus mutans Displays Altered Stress Responses While Enhancing Biofilm Formation by Lactobacillus casei in Mixed-Species Consortium.

Authors:  Zezhang T Wen; Sumei Liao; Jacob P Bitoun; Arpan De; Ashton Jorgensen; Shihai Feng; Xiaoming Xu; Patrick S G Chain; Page W Caufield; Hyun Koo; Yihong Li
Journal:  Front Cell Infect Microbiol       Date:  2017-12-20       Impact factor: 5.293

Review 6.  Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria.

Authors:  Jean Guy LeBlanc; Florian Chain; Rebeca Martín; Luis G Bermúdez-Humarán; Stéphanie Courau; Philippe Langella
Journal:  Microb Cell Fact       Date:  2017-05-08       Impact factor: 5.328

7.  CRISPR-Cas9-assisted recombineering in Lactobacillus reuteri.

Authors:  Jee-Hwan Oh; Jan-Peter van Pijkeren
Journal:  Nucleic Acids Res       Date:  2014-07-29       Impact factor: 16.971
  7 in total

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