OBJECTIVE: Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter pylori infection by means of Meta-analysis. METHODS: To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2, calculating the odds ratio and 95% confidence interval, then drawing funnel plot. Results The total sample size is 3165, cases and controls are 1330 and 1835, respectively. The pooled OR is 1.36, and 95% confidence interval 1.01, 1.82. The graphical funnel plot appearing asymmetrical, but analyzing by sensitivity analysis and fail-safe number calculation. The results are affected by publication bias. CONCLUSION: The results of our Meta-analysis show that Helicobacter pylori infection is a possible risk of colorectal cancer.
OBJECTIVE: Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter pylori infection by means of Meta-analysis. METHODS: To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2, calculating the odds ratio and 95% confidence interval, then drawing funnel plot. Results The total sample size is 3165, cases and controls are 1330 and 1835, respectively. The pooled OR is 1.36, and 95% confidence interval 1.01, 1.82. The graphical funnel plot appearing asymmetrical, but analyzing by sensitivity analysis and fail-safe number calculation. The results are affected by publication bias. CONCLUSION: The results of our Meta-analysis show that Helicobacter pylori infection is a possible risk of colorectal cancer.
Authors: Vlado Antonic; Alexander Stojadinovic; Kent E Kester; Peter J Weina; Björn Ldm Brücher; Mladjan Protic; Itzhak Avital; Mina Izadjoo Journal: J Cancer Date: 2013-03-15 Impact factor: 4.207
Authors: Hassan Brim; Marwah Zahaf; Adeyinka O Laiyemo; Mehdi Nouraie; Guillermo I Pérez-Pérez; Duane T Smoot; Edward Lee; Hadie Razjouyan; Hassan Ashktorab Journal: BMC Cancer Date: 2014-04-28 Impact factor: 4.430