Literature DB >> 195652

Evidence for intracellular amyloid formation in myeloma.

C R Kjeldsberg, H J Eyre, H Totzke.   

Abstract

Evidence for intracellular formation of amyloid fibrils in a patient with kappa light-chain myeloma is described. Amyloid fibrils were seen as intracytoplasmic inclusions within plasma cells, histiocytes, renal tubule cells, and possibly in hepatocytes. Extracellular amyloid was also present. The electron microscopic studies suggest that amyloid fibrils may form in the Golgi apparatus and within lysosomes.

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Year:  1977        PMID： 195652

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  8 in total

1.  Amyloid neuropathy: immunocytochemical localization of intra- and extracellular immunoglobulin light chains.

Authors:  C Sommer; J M Schröder
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

2.  Amyloidosis of the stomach. Report of a case with ultrastructure.

Authors:  M Balázs
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1981

3.  Electron-microscopic examination of primary diffuse tracheobronchial amyloidosis. Role of fibroblasts in amyloid formation.

Authors:  M Balázs
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1983

4.  Ultrastructural evidence for intracellular formation of amyloid fibrils in macrophages.

Authors:  M Takahashi; T Yokota; H Kawano; T Gondo; T Ishihara; F Uchino
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989

5.  Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2.

Authors:  Bonnie K Arendt; Marina Ramirez-Alvarado; Laura A Sikkink; Jonathan J Keats; Gregory J Ahmann; Angela Dispenzieri; Rafael Fonseca; Rhett P Ketterling; Ryan A Knudson; Erin M Mulvihill; Renee C Tschumper; Xiaosheng Wu; Steven R Zeldenrust; Diane F Jelinek
Journal:  Blood       Date:  2008-06-20       Impact factor: 22.113

6.  Generalized crystal-storing histiocytosis as a presentation of multiple myeloma: a case with a possible pro-aggregation defect in the immunoglobulin heavy chain.

Authors:  Bolesław Papla; Paweł Spólnik; Ewa Rzenno; Andrzej Zduńczyk; Zbigniew Rudzki; Krzysztof Okoń; Wojciech Szczepański; Wojciech Dabroś; Jerzy Stachura
Journal:  Virchows Arch       Date:  2004-05-12       Impact factor: 4.064

7.  Multiple myeloma of the serosa coat.

Authors:  C Görg; G Adler; K Görg; K H Pflüger; K Havemann
Journal:  J Cancer Res Clin Oncol       Date:  1988       Impact factor: 4.553

8.  Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains.

Authors:  J L Dul; D P Davis; E K Williamson; F J Stevens; Y Argon
Journal:  J Cell Biol       Date:  2001-02-19       Impact factor: 10.539
  8 in total

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