Literature DB >> 19564372

Vancomycin and daptomycin pharmacodynamics differ against a site-directed Staphylococcus epidermidis mutant displaying the small-colony-variant phenotype.

Marina Wu1, Christof von Eiff, Nahed Al Laham, Brian T Tsuji.   

Abstract

Catheter-related bloodstream infections due to slow-growing Staphylococcus epidermidis small-colony variants (SCVs) are extremely difficult to treat. Daptomycin and vancomycin pharmacodynamics were evaluated against a site-directed hemB mutant of S. epidermidis displaying the SCV phenotype and compared to that of the parental strain. The maximal killing effect decreased by 7.7-fold for vancomycin and 1.5-fold for daptomycin against the SCV mutant and were well characterized by a Hill-type mathematical model (R2 > 0.97).

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19564372      PMCID： PMC2737885          DOI： 10.1128/AAC.01597-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections.

Authors:  Richard A Proctor; Christof von Eiff; Barbara C Kahl; Karsten Becker; Peter McNamara; Mathias Herrmann; Georg Peters
Journal:  Nat Rev Microbiol       Date:  2006-04       Impact factor: 60.633

Review 2.  Pathogenesis of infections due to coagulase-negative staphylococci.

Authors:  Christof von Eiff; Georg Peters; Christine Heilmann
Journal:  Lancet Infect Dis       Date:  2002-11       Impact factor: 25.071

3.  Bloodstream infections caused by small-colony variants of coagulase-negative staphylococci following pacemaker implantation.

Authors:  C von Eiff; P Vaudaux; B C Kahl; D Lew; S Emler; A Schmidt; G Peters; R A Proctor
Journal:  Clin Infect Dis       Date:  1999-10       Impact factor: 9.079

4.  Characterization of Tn917 insertion mutants of Staphylococcus epidermidis affected in biofilm formation.

Authors:  C Heilmann; C Gerke; F Perdreau-Remington; F Götz
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

5.  The emergence of decreased susceptibility to vancomycin in Staphylococcus epidermidis.

Authors:  D O Garrett; E Jochimsen; K Murfitt; B Hill; S McAllister; P Nelson; R V Spera; R K Sall; F C Tenover; J Johnston; B Zimmer; W R Jarvis
Journal:  Infect Control Hosp Epidemiol       Date:  1999-03       Impact factor: 3.254

Review 6.  The small colony variant (SCV) concept -- the role of staphylococcal SCVs in persistent infections.

Authors:  Christof von Eiff; Georg Peters; Karsten Becker
Journal:  Injury       Date:  2006-05       Impact factor: 2.586

7.  Quorum-sensing control of biofilm factors in Staphylococcus epidermidis.

Authors:  Cuong Vuong; Christiane Gerke; Greg A Somerville; Elizabeth R Fischer; Michael Otto
Journal:  J Infect Dis       Date:  2003-08-11       Impact factor: 5.226

8.  Prosthetic valve endocarditis due to small-colony staphylococcal variants.

Authors:  L M Baddour; G D Christensen
Journal:  Rev Infect Dis       Date:  1987 Nov-Dec

9.  Physiology and antibiotic susceptibility of Staphylococcus aureus small colony variants.

Authors:  Nicole Baumert; Christof von Eiff; Franziska Schaaff; Georg Peters; Richard A Proctor; Hans-Georg Sahl
Journal:  Microb Drug Resist       Date:  2002       Impact factor: 3.431

10.  Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

Authors:  Brian T Tsuji; Christof von Eiff; Pamela A Kelchlin; Alan Forrest; Patrick F Smith
Journal:  Antimicrob Agents Chemother       Date:  2008-02-19       Impact factor: 5.191
View more
  1 in total

Review 1.  The road to success of coagulase-negative staphylococci: clinical significance of small colony variants and their pathogenic role in persistent infections.

Authors:  Agnieszka Bogut; Agnieszka Magryś
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2021-07-23       Impact factor: 3.267
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.