Literature DB >> 19564109

Efficient synthesis of 3,3-diheteroaromatic oxindole analogues and their in vitro evaluation for spermicidal potential.

Priyankar Paira1, Abhijit Hazra, Shrabanti Kumar, Rupankar Paira, Krishnendu B Sahu, Subhendu Naskar, Pritam Saha, Shyamal Mondal, Arindam Maity, Sukdeb Banerjee, Nirup B Mondal.   

Abstract

Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I(2) in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19564109     DOI： 10.1016/j.bmcl.2009.06.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles.

Authors:  Bing Lin; Zhi-Yong Chen; Huan-Huan Liu; Qi-Di Wei; Ting-Ting Feng; Ying Zhou; Can Wang; Xiong-Li Liu; Wei-Cheng Yuan
Journal:  Molecules       Date:  2017-05-13       Impact factor: 4.411

2.  Success or Failure of Chiral Crystallization of Similar Heterocyclic Compounds.

Authors:  Cyprian M Chunkang; Iris E Ikome; Emmanuel N Nfor; Yuta Mitani; Natsuki Katsuumi; Tomoyuki Haraguchi; Takashiro Akitsu
Journal:  Molecules       Date:  2020-12-02       Impact factor: 4.411

3.  One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions.

Authors:  Hao Lu; Yuxuan Liu; Wei Deng; Renhua Qiu; Jiannan Xiang
Journal:  Front Chem       Date:  2022-02-04       Impact factor: 5.221

4.  Effective Synthesis and Biological Evaluation of Natural and Designed Bis(indolyl)methanes via Taurine-Catalyzed Green Approach.

Authors:  Kailas A Chavan; Manjari Shukla; Amar Nath Singh Chauhan; Sushobhan Maji; Ghanshyam Mali; Sudipta Bhattacharyya; Rohan D Erande
Journal:  ACS Omega       Date:  2022-03-16

5.  Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones.

Authors:  Mardi Santoso; Li Lin Ong; Nur Pasca Aijijiyah; First Ambar Wati; Azminah Azminah; Rose Malina Annuur; Arif Fadlan; Zaher M A Judeh
Journal:  Heliyon       Date:  2022-03-04

Review 6.  Chemistry of trisindolines: natural occurrence, synthesis and bioactivity.

Authors:  First Ambar Wati; Mardi Santoso; Ziad Moussa; Sri Fatmawati; Arif Fadlan; Zaher M A Judeh
Journal:  RSC Adv       Date:  2021-07-21       Impact factor: 4.036

7.  Spermicidal and contraceptive potential of desgalactotigonin: a prospective alternative of nonoxynol-9.

Authors:  Debanjana Chakraborty; Arindam Maity; Tarun Jha; Nirup Bikash Mondal
Journal:  PLoS One       Date:  2014-09-22       Impact factor: 3.240

8.  Three-component synthesis of new unsymmetrical oxindoles via Friedel-Crafts type reaction.

Authors:  Somayeh Ahadi; Leila Moafi; Afsaneh Feiz; Ayoob Bazgir
Journal:  Tetrahedron       Date:  2011-03-09       Impact factor: 2.457

9.  Silica-Coated Magnetic-Nanoparticle-Supported DABCO-Derived Acidic Ionic Liquid for the Efficient Synthesis of Bioactive 3,3-Di(indolyl)indolin-2-ones.

Authors:  Radhika Gupta; Manavi Yadav; Rashmi Gaur; Gunjan Arora; Pooja Rana; Priya Yadav; Alok Adholeya; Rakesh K Sharma
Journal:  ACS Omega       Date:  2019-12-06
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.