Literature DB >> 1956398

Structure and functional properties of human general transcription factor IIE.

M G Peterson1, J Inostroza, M E Maxon, O Flores, A Admon, D Reinberg, R Tjian.   

Abstract

The general transcription factor IIE (TFIIE) is an essential component of the eukaryotic RNA polymerase II initiation complex. We have isolated human complementary DNA clones for both the subunits of TFIIE. Using purified recombinant proteins we find that both subunits are essential to form a stable preinitiation complex and to reconstitute basal-level and Sp1-activated transcription in vitro. Analysis of their predicted amino-acid sequences reveals several intriguing structural motifs that could provide insight into the role of TFIIE in transcription initiation.

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Year:  1991        PMID： 1956398     DOI： 10.1038/354369a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  70 in total

1.  Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription.

Authors:  M E Martin; A J Berk
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

2.  Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions.

Authors:  N H Kuldell; S Buratowski
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

3.  Photo-cross-linking of a purified preinitiation complex reveals central roles for the RNA polymerase II mobile clamp and TFIIE in initiation mechanisms.

Authors:  Diane Forget; Marie-France Langelier; Cynthia Thérien; Vincent Trinh; Benoit Coulombe
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272

4.  Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences.

Authors:  Y Ohkuma; S Hashimoto; R G Roeder; M Horikoshi
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

5.  Structural conservation of putative functional motifs between Xenopus and human TFIIE-beta.

Authors:  Y Ohkuma; S Hashimoto; R G Roeder; M Horikoshi
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

6.  Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB.

Authors:  S Yamashita; K Wada; M Horikoshi; D W Gong; T Kokubo; K Hisatake; N Yokotani; S Malik; R G Roeder; Y Nakatani
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

Review 7.  The basic RNA polymerase II transcriptional machinery.

Authors:  R Weinmann
Journal:  Gene Expr       Date:  1992

8.  Inhibition of the association of RNA polymerase II with the preinitiation complex by a viral transcriptional repressor.

Authors:  G Lee; J Wu; P Luu; P Ghazal; O Flores
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-19       Impact factor: 11.205

9.  A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.

Authors:  A Shimamoto; S Kitao; K Ichikawa; N Suzuki; Y Yamabe; O Imamura; Y Tokutake; M Satoh; T Matsumoto; J Kuromitsu; H Kataoka; K Sugawara; M Sugawara; M Sugimoto; M Goto; Y Furuichi
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205

10.  Effect of the non-conserved N-terminus on the DNA binding activity of the yeast TATA binding protein.

Authors:  R Kuddus; M C Schmidt
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971
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