Literature DB >> 19563498

Undetected factor VIII in a patient with type 3 von Willebrands disease mistaken as severe haemophilia A.

A M Mullah-Ali1, A K Chan, D Lillicrap, K Decker, W Seroski, K Moffat, I Walker, M K Pai.   

Abstract

von Willebrand disease (VWD) type 3 is a rare disorder characterized by absent or <0.1 UmL(-1) of ristocetin cofactor (VWF:RCo), and a very low level of factor VIII (FVIII:C). A total absence of FVIII:C has never been reported in type 3 VWD. This case illustrates the effect of severe von Willebrand factor (VWF) deficiency on the factor VIII level.

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Year:  2009        PMID: 19563498     DOI: 10.1111/j.1365-2516.2009.02062.x

Source DB:  PubMed          Journal:  Haemophilia        ISSN: 1351-8216            Impact factor:   4.287


  1 in total

1.  Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A.

Authors:  Qizhen Shi; Scot A Fahs; Erin L Kuether; Brian C Cooley; Hartmut Weiler; Robert R Montgomery
Journal:  Blood       Date:  2010-07-06       Impact factor: 22.113

  1 in total

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