| Literature DB >> 19563400 |
Kei Ishibashi1, Tadahiko Tokumoto, Hiroki Shirakawa, Koichi Hashimoto, Nobuhiro Kushida, Tomohiko Yanagida, Keiichi Shishido, Ken Aikawa, Osamu Yamaguchi, Hiroshi Toma, Kazunari Tanabe, Tatsuo Suzutani.
Abstract
The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies.Entities:
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Year: 2009 PMID： 19563400 DOI： 10.1111/j.1348-0421.2009.00134.x
Source DB: PubMed Journal: Microbiol Immunol ISSN： 0385-5600 Impact factor: 1.955