Literature DB >> 19562647

Physiologically based pharmacokinetic (PBPK) modeling and simulation: applications in lead optimization.

Sheila Annie Peters1, Anna-Lena Ungell, Hugues Dolgos.   

Abstract

Physiologically based pharmacokinetics (PBPK) models are increasingly being used in the lead optimization (LO) process. Although there are currently few literature reports of the application of PBPK, the scope of PBPK modeling is expanding and there is a steady increase in the number of publications in this field. Recent publications covering four important areas of the application of PBPK modeling in LO have been reviewed.

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Year:  2009        PMID： 19562647

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  4 in total

1.  BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.

Authors:  John F Graf; Bernhard J Scholz; Maria I Zavodszky
Journal:  J Pharmacokinet Pharmacodyn       Date:  2011-12-10       Impact factor: 2.745

2.  A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse.

Authors:  M D McSweeney; T Wessler; L S L Price; E C Ciociola; L B Herity; J A Piscitelli; W C Zamboni; M G Forest; Y Cao; S K Lai
Journal:  J Control Release       Date:  2018-06-05       Impact factor: 9.776

Review 3.  Review of the environmental prenatal exposome and its relationship to maternal and fetal health.

Authors:  Julia E Rager; Jacqueline Bangma; Celeste Carberry; Alex Chao; Jarod Grossman; Kun Lu; Tracy A Manuck; Jon R Sobus; John Szilagyi; Rebecca C Fry
Journal:  Reprod Toxicol       Date:  2020-02-23       Impact factor: 3.143

Review 4.  PBPK modeling and simulation in drug research and development.

Authors:  Xiaomei Zhuang; Chuang Lu
Journal:  Acta Pharm Sin B       Date:  2016-06-23       Impact factor: 11.413
  4 in total

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