| Literature DB >> 19561636 |
Sanjeev Bhattacharyya1, Dorothy M Gujral, Christos Toumpanakis, Gilles Dreyfus, Brian R Davidson, Joseph Davar, Martyn E Caplin.
Abstract
BACKGROUND: A 48-year-old man presented with diarrhea, flushing, abdominal pain and weight loss of 10 kg over a 6-month period. He subsequently developed dyspnea on exertion. INVESTIGATIONS: Physical examination, laboratory tests, CT of the abdomen, liver biopsy, echocardiography, immunohistochemistry staining of the biopsy specimen for neuroendocrine markers including chromogranin A, synaptophysin and protein gene product 9.5, and (111)In-pentetreotide scintigraphy (Octreoscan). DIAGNOSIS: Carcinoid tumor of midgut origin with large segment 3 liver metastasis. Carcinoid syndrome and carcinoid heart disease. MANAGEMENT: Symptomatic relief with somatostatin analog therapy and subsequent resection of the segment 3 liver metastasis. Tricuspid and pulmonary valve replacement.Entities:
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Year: 2009 PMID： 19561636 DOI： 10.1038/nrclinonc.2009.70
Source DB: PubMed Journal: Nat Rev Clin Oncol ISSN： 1759-4774 Impact factor: 66.675