PURPOSE OF REVIEW: Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made. RECENT FINDINGS: With the increase in consumption of NSAIDs, these have become one of the most common drugs inducing hypersensitivity reactions. Although cross-intolerance reactions are the most common, a significant proportion is selective responses. As specific IgE antibodies are not always found, there is only indirect evidence supporting an IgE-mediated mechanism in selective NSAID reactors. SUMMARY: Selective immediate reactions to NSAIDs must be considered when a patient develops urticaria or anaphylaxis after intake of one drug with good tolerance to drugs from other groups or even a drug from the same group with a slightly different chemical structure. Further research is required to identify the antigenic determinant structures recognized.
PURPOSE OF REVIEW: Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made. RECENT FINDINGS: With the increase in consumption of NSAIDs, these have become one of the most common drugs inducing hypersensitivity reactions. Although cross-intolerance reactions are the most common, a significant proportion is selective responses. As specific IgE antibodies are not always found, there is only indirect evidence supporting an IgE-mediated mechanism in selective NSAID reactors. SUMMARY: Selective immediate reactions to NSAIDs must be considered when a patient develops urticaria or anaphylaxis after intake of one drug with good tolerance to drugs from other groups or even a drug from the same group with a slightly different chemical structure. Further research is required to identify the antigenic determinant structures recognized.
Authors: Diana Pérez-Alzate; Natalia Blanca-López; Inmaculada Doña; José A Agúndez; Elena García-Martín; José A Cornejo-García; James R Perkins; Miguel Blanca; Gabriela Canto Journal: Front Pharmacol Date: 2016-07-20 Impact factor: 5.810
Authors: Enrique Gómez; Maria Jose Torres; Cristobalina Mayorga; Miguel Blanca Journal: Allergy Asthma Immunol Res Date: 2012-05-30 Impact factor: 5.764
Authors: Adriana Ariza; Elena García-Martín; María Salas; María I Montañez; Cristobalina Mayorga; Natalia Blanca-Lopez; Inmaculada Andreu; James Perkins; Miguel Blanca; José A G Agúndez; María J Torres Journal: Sci Rep Date: 2016-03-31 Impact factor: 4.379