| Literature DB >> 19560920 |
Anthony R Martin1, Thomas Lavergne, Jean-Jacques Vasseur, Françoise Debart.
Abstract
New base-labile acyloxymethyl groups were evaluated to protect 2'-OH functions of ribonucleotides for regular RNA synthesis in order to shorten the deprotection procedure upon ammonia. These same acetalester groups were assessed in 2'-modified proRNA as biolabile 2'-protections removable by cell enzymes to generate parent RNA. Demasking of 2'-modified pro-uridylates was studied in cell extracts.Entities:
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Year: 2009 PMID： 19560920 DOI： 10.1016/j.bmcl.2009.06.015
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823