Literature DB >> 1956054

Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.

A Krohn1, S Redshaw, J C Ritchie, B J Graves, M H Hatada.   

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Year:  1991        PMID： 1956054     DOI： 10.1021/jm00115a028

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  41 in total

1.  Inhibition and substrate recognition--a computational approach applied to HIV protease.

Authors:  H M Vinkers; M R de Jonge; E D Daeyaert; J Heeres; L M H Koymans; J H van Lenthe; P J Lewi; H Timmerman; P A J Janssen
Journal:  J Comput Aided Mol Des       Date:  2003-09       Impact factor: 3.686

2.  Insights into saquinavir resistance in the G48V HIV-1 protease: quantum calculations and molecular dynamic simulations.

Authors:  Kitiyaporn Wittayanarakul; Ornjira Aruksakunwong; Suwipa Saen-oon; Wasun Chantratita; Vudhichai Parasuk; Pornthep Sompornpisut; Supot Hannongbua
Journal:  Biophys J       Date:  2004-11-12       Impact factor: 4.033

3.  Rationale for more diverse inhibitors in competition with substrates in HIV-1 protease.

Authors:  Nevra Ozer; Celia A Schiffer; Turkan Haliloglu
Journal:  Biophys J       Date:  2010-09-08       Impact factor: 4.033

Review 4.  Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

Authors:  Arun K Ghosh; Heather L Osswald; Gary Prato
Journal:  J Med Chem       Date:  2016-01-22       Impact factor: 7.446

5.  Atomistic simulations of the HIV-1 protease folding inhibition.

Authors:  Gennady Verkhivker; Guido Tiana; Carlo Camilloni; Davide Provasi; Ricardo A Broglia
Journal:  Biophys J       Date:  2008-03-28       Impact factor: 4.033

6.  Dynamic undocking and the quasi-bound state as tools for drug discovery.

Authors:  Sergio Ruiz-Carmona; Peter Schmidtke; F Javier Luque; Lisa Baker; Natalia Matassova; Ben Davis; Stephen Roughley; James Murray; Rod Hubbard; Xavier Barril
Journal:  Nat Chem       Date:  2016-11-14       Impact factor: 24.427

7.  3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.

Authors:  Wayne J Thompson; Arun K Ghosh; M Katharine Holloway; Hee Yoon Lee; Peter M Munson; John E Schwering; Jenny Wai; Paul L Darke; Joan Zugay; Emilio A Emini; William A Schleif; Joel R Huff; Paul S Anderson
Journal:  J Am Chem Soc       Date:  1993-01-01       Impact factor: 15.419

8.  Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.

Authors:  Jennifer E Foulkes; Moses Prabu-Jeyabalan; Deyna Cooper; Gavin J Henderson; Janera Harris; Ronald Swanstrom; Celia A Schiffer
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

9.  Identification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance.

Authors:  Sidhartha Chaudhury; Jeffrey J Gray
Journal:  Structure       Date:  2009-12-09       Impact factor: 5.006

Review 10.  Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.

Authors:  Eric Lefebvre; Celia A Schiffer
Journal:  AIDS Rev       Date:  2008 Jul-Sep       Impact factor: 2.500
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