Literature DB >> 19560525

A new cytotoxic casbane diterpene from Euphorbia pekinensis.

Qiao-Li Liang1, Chuan-Chao Dai, Ji-Hong Jiang, Yu-Ping Tang, Jin-Ao Duan.   

Abstract

A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5alpha-hydroxy-1betaH,2alphaH-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested.

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Year:  2009        PMID： 19560525     DOI： 10.1016/j.fitote.2009.06.014

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  10 in total

1.  Molecular characterization and expression analysis of a gene encoding for farnesyl diphosphate synthase from Euphorbia pekinensis Rupr.

Authors:  Xiaoying Cao; Ting Yin; Qian Miao; Changgen Li; Xiuyun Ju; Yong Sun; Jihong Jiang
Journal:  Mol Biol Rep       Date:  2011-05-26       Impact factor: 2.316

2.  Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest.

Authors:  Nan Li; Donghai Zheng; Jie Xue; Weixing Guo; Jie Shi; Juxian Sun; Chongde Lu; Weida Zheng; Mengchao Wu; Shuqun Cheng
Journal:  Exp Ther Med       Date:  2015-03-13       Impact factor: 2.447

3.  Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii.

Authors:  Chun-Shuai Huang; Shi-Hong Luo; Yao-Lan Li; Chun-Huan Li; Juan Hua; Yan Liu; Shu-Xi Jing; Ying Wang; Min-Jie Yang; Sheng-Hong Li
Journal:  Nat Prod Bioprospect       Date:  2014-04-09

4.  Toxicity of Pekinenin C from Euphorbia Pekinensis Radix on Rat Small Intestinal Crypt Epithelial Cell and Its Apoptotic Mechanism.

Authors:  Yudan Cao; Fangfang Cheng; Weifeng Yao; Beihua Bao; Kaicheng Zhang; Li Zhang; Anwei Ding
Journal:  Int J Mol Sci       Date:  2016-06-02       Impact factor: 5.923

5.  Phytochemical Screening and Cytotoxic Evaluation of Euphorbia turcomanica on Hela and HT-29 Tumor Cell Lines.

Authors:  Mehdi Aliomrani; Abbas Jafarian; Behzad Zolfaghari
Journal:  Adv Biomed Res       Date:  2017-06-06

6.  Laxative Effects of Total Diterpenoids Extracted from the Roots of Euphorbia pekinensis Are Attributable to Alterations of Aquaporins in the Colon.

Authors:  Kuilong Wang; Lian Liu; Jianyu Huang; Hongli Yu; Hao Wu; Yu Duan; Xiaobing Cui; Xingde Zhang; Liping Liu; Wei Wang
Journal:  Molecules       Date:  2017-03-14       Impact factor: 4.411

7.  Metabolomic evaluation of Euphorbia pekinensis induced nephrotoxicity in rats.

Authors:  Zhenzhen Liu; Yan Zeng; Pengyi Hou
Journal:  Pharm Biol       Date:  2018-12       Impact factor: 3.503

8.  Collective Total Synthesis of Casbane Diterpenes: One Strategy, Multiple Targets.

Authors:  Lorenz E Löffler; Conny Wirtz; Alois Fürstner
Journal:  Angew Chem Int Ed Engl       Date:  2021-01-28       Impact factor: 15.336

9.  New casbane diterpenoids from a South China Sea soft coral, Sinularia sp.

Authors:  Jian Yin; Min Zhao; Minshan Ma; Yuping Xu; Zheng Xiang; Yuepiao Cai; Jianyong Dong; Xinxiang Lei; Kexin Huang; Pengcheng Yan
Journal:  Mar Drugs       Date:  2013-02-06       Impact factor: 5.118

Review 10.  Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984-2019).

Authors:  Maryam Fattahian; Mustafa Ghanadian; Zulfiqar Ali; Ikhlas A Khan
Journal:  Phytochem Rev       Date:  2020-04-13       Impact factor: 7.741
  10 in total

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