| Literature DB >> 19559726 |
Henoch Sangjoon Hong1, Nupur Bhatnagar, Matthias Ballmaier, Ulrich Schubert, Peter Henklein, Thorsten Volgmann, Hans Heiken, Reinhold E Schmidt, Dirk Meyer-Olson.
Abstract
HIV Vpr is known for its immunomodulatory capacities including its impairment of NK cell functions. However, the role of pDCs in this context remains elusive. We show that synthetic Vpr substantially inhibits type I IFN production by pDCs without inducing apoptosis in pDCs. Furthermore, we found that exogenous Vpr compromises subsequent pDC/NK interplay as shown by diminished IFN-gamma production by NK cells. Thus, Vpr-mediated dysregulation of IFN-alpha and IFN-gamma production affects key components of the innate immune response supporting an essential role of Vpr in HIV pathogenesis.Entities:
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Year: 2009 PMID： 19559726 DOI： 10.1016/j.imlet.2009.06.008
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685