BACKGROUND: No randomized controlled trial (RCT) has compared all European-licensed standard- and double-dose PPIs for the healing of severe erosive oesophagitis. AIM: To compare the effectiveness of licensed doses of PPIs for healing severe erosive oesophagitis (i.e. esomeprazole 40 mg, lansoprazole 30 mg, omeprazole 20 mg and 40 mg, pantoprazole 40 mg and rabeprazole 20 mg). METHODS: Systematic review of CENTRAL, EMBASE and MEDLINE for RCTs in patients with erosive oesophagitis (completed October 2008). Endoscopically verified healing rates at 4 and 8 weeks were extracted and re-calculated if not analysed by intention-to-treat. A mixed treatment comparison was used to combine direct treatment comparisons with indirect trial evidence while maintaining randomization. Odds ratios (OR) are reported compared to omeprazole 20 mg. RESULTS: A total of 3021 papers were identified in the literature search; 12 were of sufficient quality to be included in the analysis. Insufficient data were available to included rabeprazole. Esomeprazole 40 mg was found to provide significantly higher healing rates at 4 weeks [OR 1.84, 95% Credible Interval (95% CrI): 1.50 to 2.22] and 8 weeks (OR 1.91, 95% CrI: 1.13 to 2.88). No other PPI investigated had significantly higher healing rates than omeprazole 20 mg. CONCLUSION: Esomeprazole 40 mg consistently demonstrates higher healing rates compared with licensed standard- and double-dose PPIs.
BACKGROUND: No randomized controlled trial (RCT) has compared all European-licensed standard- and double-dose PPIs for the healing of severe erosive oesophagitis. AIM: To compare the effectiveness of licensed doses of PPIs for healing severe erosive oesophagitis (i.e. esomeprazole 40 mg, lansoprazole 30 mg, omeprazole 20 mg and 40 mg, pantoprazole 40 mg and rabeprazole 20 mg). METHODS: Systematic review of CENTRAL, EMBASE and MEDLINE for RCTs in patients with erosive oesophagitis (completed October 2008). Endoscopically verified healing rates at 4 and 8 weeks were extracted and re-calculated if not analysed by intention-to-treat. A mixed treatment comparison was used to combine direct treatment comparisons with indirect trial evidence while maintaining randomization. Odds ratios (OR) are reported compared to omeprazole 20 mg. RESULTS: A total of 3021 papers were identified in the literature search; 12 were of sufficient quality to be included in the analysis. Insufficient data were available to included rabeprazole. Esomeprazole 40 mg was found to provide significantly higher healing rates at 4 weeks [OR 1.84, 95% Credible Interval (95% CrI): 1.50 to 2.22] and 8 weeks (OR 1.91, 95% CrI: 1.13 to 2.88). No other PPI investigated had significantly higher healing rates than omeprazole 20 mg. CONCLUSION:Esomeprazole 40 mg consistently demonstrates higher healing rates compared with licensed standard- and double-dose PPIs.
Authors: S Roman; L Keefer; H Imam; P Korrapati; B Mogni; K Eident; L Friesen; P J Kahrilas; Z Martinovich; J E Pandolfino Journal: Neurogastroenterol Motil Date: 2015-09-04 Impact factor: 3.598
Authors: Ans Pauwels; Charlotte Broers; Tim Vanuytsel; Nicolas Pardon; Silvia Cocca; Sabine Roman; Frank Zerbib; Jan Tack; Ricard Farré Journal: United European Gastroenterol J Date: 2017-12-17 Impact factor: 4.623
Authors: K Ashida; Y Sakurai; A Nishimura; K Kudou; N Hiramatsu; E Umegaki; K Iwakiri; T Chiba Journal: Aliment Pharmacol Ther Date: 2015-07-22 Impact factor: 8.171
Authors: Diana M Sobieraj; Joseph C Cappelleri; William L Baker; Olivia J Phung; C Michael White; Craig I Coleman Journal: BMJ Open Date: 2013-07-21 Impact factor: 2.692
Authors: Frederik Hvid-Jensen; Rikke B Nielsen; Lars Pedersen; Peter Funch-Jensen; Asbjørn Mohr Drewes; Finn B Larsen; Reimar W Thomsen Journal: Clin Epidemiol Date: 2013-12-04 Impact factor: 4.790