OBJECTIVE: To assess the psychometric validity, reliability, responsiveness, and minimal important differences of the Diabetes Symptoms Checklist-Revised (DSC-R), a widely used patient-reported outcome measure of diabetes symptom distress. RESEARCH DESIGN AND METHODS: Psychometric validity of the DSC-R was assessed using blinded data from a large-scale trial of approximately 4000 type 2 diabetes patients. Confirmatory factorial analysis (CFA) and multitrait analysis were used to examine the construct validity of the structure of DSC-R. DSC-R internal consistency, discriminative validity, and responsiveness were also assessed. Distribution and anchor-based methods were used to estimate minimal important differences for DSC-R domains. RESULTS:Mean age of the sample was 56 years, 42% were female, 88% were Caucasian. Patients had a mean body mass index (BMI) of 32.2 and mean glucose-fasting level of 151.7 md/dl. CFA and multitrait analysis indicated that the scoring of the DSC-R has acceptable construct validity. Item-scale correlations ranged from 0.44 to 0.78. Cronbach's alpha coefficients ranged from 0.69 to 0.87. At baseline, DSC-R scores were higher among patients with higher BMI scores (P < 0.0001), supporting the discriminative validity of the DSC-R. Minimal important difference estimates ranged from 0.39 to 0.60 points when using distribution methods and from 0.00 to 0.33 when estimated using anchor-based methods. CONCLUSIONS: The DSC-R demonstrated excellent psychometric properties when tested in a large-scale diabetes clinical trial. Responsiveness and test-retest reliability of the DSC-R warrant further evaluation.
RCT Entities:
OBJECTIVE: To assess the psychometric validity, reliability, responsiveness, and minimal important differences of the Diabetes Symptoms Checklist-Revised (DSC-R), a widely used patient-reported outcome measure of diabetes symptom distress. RESEARCH DESIGN AND METHODS: Psychometric validity of the DSC-R was assessed using blinded data from a large-scale trial of approximately 4000 type 2 diabetespatients. Confirmatory factorial analysis (CFA) and multitrait analysis were used to examine the construct validity of the structure of DSC-R. DSC-R internal consistency, discriminative validity, and responsiveness were also assessed. Distribution and anchor-based methods were used to estimate minimal important differences for DSC-R domains. RESULTS: Mean age of the sample was 56 years, 42% were female, 88% were Caucasian. Patients had a mean body mass index (BMI) of 32.2 and mean glucose-fasting level of 151.7 md/dl. CFA and multitrait analysis indicated that the scoring of the DSC-R has acceptable construct validity. Item-scale correlations ranged from 0.44 to 0.78. Cronbach's alpha coefficients ranged from 0.69 to 0.87. At baseline, DSC-R scores were higher among patients with higher BMI scores (P < 0.0001), supporting the discriminative validity of the DSC-R. Minimal important difference estimates ranged from 0.39 to 0.60 points when using distribution methods and from 0.00 to 0.33 when estimated using anchor-based methods. CONCLUSIONS: The DSC-R demonstrated excellent psychometric properties when tested in a large-scale diabetes clinical trial. Responsiveness and test-retest reliability of the DSC-R warrant further evaluation.
Authors: Juan P Frias; Bruce W Bode; Timothy S Bailey; Mark S Kipnes; Rocco Brunelle; Steven V Edelman Journal: J Diabetes Sci Technol Date: 2011-07-01
Authors: Bradley C Johnston; Kristian Thorlund; Holger J Schünemann; Feng Xie; Mohammad Hassan Murad; Victor M Montori; Gordon H Guyatt Journal: Health Qual Life Outcomes Date: 2010-10-11 Impact factor: 3.186
Authors: David C Klonoff; Lawrence Blonde; George Cembrowski; Antonio Roberto Chacra; Guillaume Charpentier; Stephen Colagiuri; George Dailey; Robert A Gabbay; Lutz Heinemann; David Kerr; Antonio Nicolucci; William Polonsky; Oliver Schnell; Robert Vigersky; Jean-François Yale Journal: J Diabetes Sci Technol Date: 2011-11-01
Authors: T R S Hajos; F Pouwer; R de Grooth; F Holleman; J W R Twisk; M Diamant; F J Snoek Journal: Qual Life Res Date: 2011-11-08 Impact factor: 4.147