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Literature DB >> 195581

Phosphatidylinositol-degrading enzymes in liver lysosomes.

Abstract

The major pathway by which liver lysosomal enzymes degrade phosphatidylinositol is through an EDTA-insensitive formation of phosphorylinositol. This is in distinct contrast with the Ca2+-dependent production of phosphorylinositol from phosphatidylinositol, which is located in the cytosol. Lysosomal enzymes can also totally deacylate phosphatidylinositol, producing glycerophosphorylinositol.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 195581 PMCID： PMC1164785 DOI： 10.1042/bj1640277

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. SPECIFIC ASSAYS OF SOME PHOSPHATASES IN SUBCELLULAR FRACTIONS OF SMALL INTESTINAL MUCOSA.

Authors: G HUEBSCHER; G R WEST
Journal: Nature Date: 1965-02-20 Impact factor: 49.962

2. Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas.

Authors: R M DAWSON
Journal: Biochim Biophys Acta Date: 1959-05

3. Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids.

Authors: P KEMP; G HUBSCHER; J N HAWTHORNE
Journal: Biochem J Date: 1961-04 Impact factor: 3.857

4. The localization of glutamate carboxypeptidase in rat liver lysosomes.

Authors: M Silink; P B Rowe
Journal: Biochim Biophys Acta Date: 1975-01-13

5. Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

Authors: Y Oron; M Löwe; Z Selinger
Journal: Mol Pharmacol Date: 1975-01 Impact factor: 4.436

Review 6. Inositol phospholipids and cell surface receptor function.

Authors: R H Michell
Journal: Biochim Biophys Acta Date: 1975-03-25

7. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

8. A microspectrophotometric method for the determination of cytochrome oxidase.

Authors: S J COOPERSTEIN; A LAZAROW
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

Review 9. Dynamic aspects of phospholipids during protein secretion.

Authors: L E Hokin
Journal: Int Rev Cytol Date: 1968

10. Specificity and other properties of lysosomal lipase of rat liver.

Authors: K Hayase; A L Tappel
Journal: J Biol Chem Date: 1970-01-10 Impact factor: 5.157

10 in total

1. Characterization of phosphoinositide-specific phospholipase C from human platelets.

Authors: V Manne; H F Kung
Journal: Biochem J Date: 1987-05-01 Impact factor: 3.857

2. Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases.

Authors: A S Malik; M G Low
Journal: Biochem J Date: 1986-12-01 Impact factor: 3.857

3. Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms.

Authors: R F Irvine; A J Letcher; R M Dawson
Journal: Biochem J Date: 1984-02-15 Impact factor: 3.857

Phosphatidylinositol-degrading enzymes in liver lysosomes.

1. SPECIFIC ASSAYS OF SOME PHOSPHATASES IN SUBCELLULAR FRACTIONS OF SMALL INTESTINAL MUCOSA.

2. Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas.

3. Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids.

4. The localization of glutamate carboxypeptidase in rat liver lysosomes.

5. Incorporation of inorganic [32P] phosphate into rat parotid phosphatidylinositol. Induction through activation of alpha adrenergic and cholinergic receptors and relation to K+ release.

Review 6. Inositol phospholipids and cell surface receptor function.

7. Protein measurement with the Folin phenol reagent.

8. A microspectrophotometric method for the determination of cytochrome oxidase.

Review 9. Dynamic aspects of phospholipids during protein secretion.

10. Specificity and other properties of lysosomal lipase of rat liver.

1. Characterization of phosphoinositide-specific phospholipase C from human platelets.

2. Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases.

3. Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms.

4. The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain.

5. sn-Glycero(3)phosphoinositol glycerophosphohydrolase. A new phosphodiesterase in rat tissues.

6. Endogenous lipolytic activities during autolysis of highly enriched hepatic lysosomes.

7. Inositol trisphosphates in carbachol-stimulated rat parotid glands.

8. Hydrolysis of membrane phospholipids by phospholipases of rat liver lysosomes.

9. Phosphatidylinositol-specific phospholipase C in fetal membranes and uterine decidua.

10. Do mammals make all their own inositol hexakisphosphate?