BACKGROUND AND AIM OF THE STUDY: A new mitral valve repair concept to treat mitral regurgitation (MR) due to valve prolapse was recently proposed. In this study, an improved design of this concept is presented, and the results of preliminary hemodynamic studies conducted in an in-vitro prolapse model are reported. METHODS: The new repair approach is based on using a web/net attached to a standard annuloplasty ring spanning the annulus of the mitral valve. Experiments were conducted in a left ventricular simulator, using native porcine mitral valves. Severe MR was created by transecting the marginal chordae to induce P2 prolapse, and also by displacing the papillary muscles basally to induce bileaflet prolapse. RESULTS: Implantation of the mitral web prevented leaflet prolapse and restored leaflet coaptation with trace mitral insufficiency, in both posterior and bileaflet prolapse. In posterior leaflet prolapse, implantation of the mitral web reduced the regurgitation volume from 10.43 +/- 3.76 ml to 2.13 +/- 1.83 ml per beat (p < 0.05). No visual damage was observed on the mitral valve leaflets after 4 h of continuous operation. CONCLUSION: Based on the study results, the mitral web may represent a feasible option to repair different types of mitral valve prolapse. The mitral web may also significantly simplify mitral valve repair for complex lesions.
BACKGROUND AND AIM OF THE STUDY: A new mitral valve repair concept to treat mitral regurgitation (MR) due to valve prolapse was recently proposed. In this study, an improved design of this concept is presented, and the results of preliminary hemodynamic studies conducted in an in-vitro prolapse model are reported. METHODS: The new repair approach is based on using a web/net attached to a standard annuloplasty ring spanning the annulus of the mitral valve. Experiments were conducted in a left ventricular simulator, using native porcine mitral valves. Severe MR was created by transecting the marginal chordae to induce P2 prolapse, and also by displacing the papillary muscles basally to induce bileaflet prolapse. RESULTS: Implantation of the mitral web prevented leaflet prolapse and restored leaflet coaptation with trace mitral insufficiency, in both posterior and bileaflet prolapse. In posterior leaflet prolapse, implantation of the mitral web reduced the regurgitation volume from 10.43 +/- 3.76 ml to 2.13 +/- 1.83 ml per beat (p < 0.05). No visual damage was observed on the mitral valve leaflets after 4 h of continuous operation. CONCLUSION: Based on the study results, the mitral web may represent a feasible option to repair different types of mitral valve prolapse. The mitral web may also significantly simplify mitral valve repair for complex lesions.
Authors: Annabel M Imbrie-Moore; Matthew H Park; Michael J Paulsen; Mark Sellke; Rohun Kulkami; Hanjay Wang; Yuanjia Zhu; Justin M Farry; Alexandra T Bourdillon; Christine Callinan; Haley J Lucian; Camille E Hironaka; Daniela Deschamps; Y Joseph Woo Journal: J R Soc Interface Date: 2020-12-02 Impact factor: 4.118
Authors: Annabel M Imbrie-Moore; Cole C Paullin; Michael J Paulsen; Frederick Grady; Hanjay Wang; Camille E Hironaka; Justin M Farry; Haley J Lucian; Y Joseph Woo Journal: Med Eng Phys Date: 2020-01-31 Impact factor: 2.242
Authors: Annabel M Imbrie-Moore; Yuanjia Zhu; Tabitha Bandy-Vizcaino; Matthew H Park; Robert J Wilkerson; Y Joseph Woo Journal: Ann Biomed Eng Date: 2021-11-03 Impact factor: 4.219
Authors: Annabel M Imbrie-Moore; Michael J Paulsen; Yuanjia Zhu; Hanjay Wang; Haley J Lucian; Justin M Farry; John W MacArthur; Michael Ma; Y Joseph Woo Journal: J Thorac Cardiovasc Surg Date: 2020-02-19 Impact factor: 5.209