| Literature DB >> 19557721 |
Daisuke Son1, Hiroko Kanda, Akihiro Yamaguchi, Kimito Kawabata, Takahisa Kawakami, Kanae Kubo, Mana Higashihara, Jun Shimizu, Hiroshi Uozaki, Shigeru Kuramochi, Yoshikata Misaki, Fujio Takeuchi, Kazuhiko Yamamoto.
Abstract
Renal involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is characterized by focal segmental crescentic and/or necrotizing glomerulonephritis. Here, we report the case of a 66-year-old woman showing myeloperoxidase (MPO)-ANCA positivity and mononeuritis multiplex whose kidney biopsy revealed severe and diffuse tubulointerstitial nephritis despite the fact that crescentic necrotizing glomerulonephritis was focal. The mechanism of tubulointerstitial injury in ANCA-associated vasculitis remains unclear. Further studies are necessary to confirm the relationship between diffuse tubulointerstitial nephritis and ANCA-associated vasculitis.Entities:
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Year: 2009 PMID： 19557721
Source DB: PubMed Journal: J Nephrol ISSN： 1121-8428 Impact factor: 3.902