Literature DB >> 19557575

FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis.

Lin Wang1, Ying Sun, Minghu Jiang, Shen Zhang, Stefan Wolfl.   

Abstract

The aim is to setup single distinguished molecular network. We constructed FOS proliferating network from 22 colorectal samples of the same GEO dataset by GRNInfer tool and DAVID based on linear programming and a decomposition procedure with integrated Kappa statistics and fuzzy heuristic clustering. In the control, we found no proliferating subnetwork. In CRC, we identified one FOS proliferating module (SFRP2, ADAMTS1, SYNPO2, VIP, ADAM33 inhibition to FOS and MGP, FOSB activation to FOS. FOS activation to IGFBP5, LGI1, GAS1 and FOS inhibition to VIP). These results may be useful for developing novel prognostic markers and therapeutic targets in CRC.

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Year:  2009        PMID： 19557575     DOI： 10.1080/07357900802672753

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  17 in total

1.  AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues.

Authors:  Lin Wang; Juxiang Huang; Minghu Jiang; Xiguang Zheng
Journal:  Tumour Biol       Date:  2010-06-08

2.  The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer.

Authors:  Xiaowan Chen; Jingxu Sun; Yongxi Song; Peng Gao; Junhua Zhao; Xuanzhang Huang; Bo Liu; Huimian Xu; Zhenning Wang
Journal:  Med Oncol       Date:  2014-09-27       Impact factor: 3.064

3.  Signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum by biocomputation.

Authors:  Lin Wang; Juxiang Huang; Minghu Jiang; Hong Lin
Journal:  J Mol Neurosci       Date:  2012-01-05       Impact factor: 3.444

4.  Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.

Authors:  Juxiang Huang; Lin Wang; Minghu Jiang; Qingchun Chen; Xiaoyu Zhang; Yangming Wang; Zhenfu Jiang; Zhongjie Zhang
Journal:  Immunol Res       Date:  2016-04       Impact factor: 2.829

5.  Cyclin-dependent kinase inhibitor 3 (CDKN3) novel cell cycle computational network between human non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) transformation.

Authors:  L Wang; L Sun; J Huang; M Jiang
Journal:  Cell Prolif       Date:  2011-06       Impact factor: 6.831

6.  Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation.

Authors:  Lin Wang; Juxiang Huang; Minghu Jiang; Hong Lin
Journal:  Immunol Res       Date:  2012-06       Impact factor: 2.829

7.  MYBPC1 computational phosphoprotein network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients.

Authors:  Lin Wang; Juxiang Huang; Minghu Jiang; Lingjun Sun
Journal:  Cell Mol Neurobiol       Date:  2011-03       Impact factor: 5.046

8.  Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network.

Authors:  Jingwen You; Lin Wang; Juxiang Huang; Minghu Jiang; Qingchun Chen; Yangming Wang; Zhenfu Jiang
Journal:  Mol Cell Biochem       Date:  2014-10-18       Impact factor: 3.396

9.  STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.

Authors:  Yuxin Wang; Anette H H van Boxel-Dezaire; HyeonJoo Cheon; Jinbo Yang; George R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-30       Impact factor: 11.205

10.  Activated PTHLH coupling feedback phosphoinositide to G-protein receptor signal-induced cell adhesion network in human hepatocellular carcinoma by systems-theoretic analysis.

Authors:  Lin Wang; Juxiang Huang; Minghu Jiang; Hong Lin; Lianxiu Qi; Haizhen Diao
Journal:  ScientificWorldJournal       Date:  2012-09-10
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