Literature DB >> 1955735

Transforming growth factor-beta: an important mediator of immunoregulation.

J H Kehrl1.   

Abstract

Transforming growth factor-beta (TGF-beta) is synthesized and secreted by a wide variety of cells, including cells of the immune system. Lymphocytes and monocytes possess high affinity TGF-beta receptors and the addition of TGF-beta to in vitro cell cultures results in significant modulation of immune function. TGF-beta inhibits the proliferation of thymocytes, T cells, B cells, and natural killer cells. Additionally, it inhibits certain differentiative functions of lymphocytes including a marked inhibition of immunoglobulin production by human B lymphocytes. TGF-beta has dichotomous actions on monocytes. It is a potent chemoattractant for monocytes and induces interleukin 1 mRNA expression while inhibiting generation of reactive oxygen intermediates and monocyte killing. Evidence is accumulating that TGF-beta regulates immune function in vivo and that overproduction of TGF-beta may be associated with immunosuppression.

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Year:  1991        PMID： 1955735     DOI： 10.1002/stem.1991.5530090502

Source DB:  PubMed          Journal:  Int J Cell Cloning        ISSN： 0737-1454


  17 in total

1.  Intracellular cytokines in blood T cells in lung transplant patients--a more relevant indicator of immunosuppression than drug levels.

Authors:  G Hodge; S Hodge; P Reynolds; M Holmes
Journal:  Clin Exp Immunol       Date:  2005-01       Impact factor: 4.330

2.  Compartmentalization of intracellular proinflammatory cytokines in bronchial intraepithelial T cells of stable lung transplant patients.

Authors:  G Hodge; S Hodge; P N Reynolds; M Holmes
Journal:  Clin Exp Immunol       Date:  2006-09       Impact factor: 4.330

3.  TGF-beta 1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells.

Authors:  C A Bonham; L Lu; R A Banas; P Fontes; A S Rao; T E Starzl; A Zeevi; A W Thomson
Journal:  Transpl Immunol       Date:  1996-09       Impact factor: 1.708

4.  Hormonal change and cytokine mRNA expression in peripheral blood mononuclear cells during the development of canine autoimmune thyroiditis.

Authors:  E-W Choi; I-S Shin; D-H Bhang; D-H Lee; B-K Bae; M-S Kang; D-Y Kim; C-Y Hwang; C-W Lee; H-Y Youn
Journal:  Clin Exp Immunol       Date:  2006-10       Impact factor: 4.330

5.  In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences.

Authors:  H M van Beuningen; P M van der Kraan; O J Arntz; W B van den Berg
Journal:  Ann Rheum Dis       Date:  1994-09       Impact factor: 19.103

6.  Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects.

Authors:  G Hodge; J Nairn; M Holmes; P N Reynolds; S Hodge
Journal:  Clin Exp Immunol       Date:  2007-07-05       Impact factor: 4.330

7.  Association of TGF-β1 +869C/T promoter polymorphism with susceptibility to autoimmune diseases: a meta-analysis.

Authors:  Li Zhang; Jun-wei Yan; Ying-Xin Wang; Ya-nan Wan; Jian-ping Li; Ping Liu; Bin Xu; Bing-xiang Wang; Wen-jia Peng; Fa-ming Pan; Jing Wang
Journal:  Mol Biol Rep       Date:  2013-05-05       Impact factor: 2.316

8.  Regulation of human CD4(+) alphabeta T-cell-receptor-positive (TCR(+)) and gammadelta TCR(+) T-cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor beta.

Authors:  R E Rojas; K N Balaji; A Subramanian; W H Boom
Journal:  Infect Immun       Date:  1999-12       Impact factor: 3.441

9.  Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation.

Authors:  Nicole S Anderson; Leslie Turner; Sandra Livingston; Ren Chen; Santo V Nicosia; Patricia A Kruk
Journal:  J Ovarian Res       Date:  2009-10-25       Impact factor: 4.234

10.  Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6).

Authors:  N A Wall; M Blessing; C V Wright; B L Hogan
Journal:  J Cell Biol       Date:  1993-01       Impact factor: 10.539
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