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Literature DB >> 1955718

Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type I in rabbits.

T Sawada¹, Y Iwahara, K Ishii, H Taguchi, H Hoshino, I Miyoshi.

Abstract

Prophylactic effect of human T cell leukemia virus type I (HTLV-I) immune globulin (HTLVIG) against milkborne transmission of HTLV-I was investigated in a rabbit model. Four litters (A-D: 7, 5, 7, and 7 offspring, respectively) born to an HTLV-I-infected rabbit were used. Litters A and D were allowed to grow normally as controls, while litters B and C were given weekly intraperitoneal inoculation of HTLVIG four times until weaning at 4.5 weeks of age. Only 1 (8.3%) of the 12 HTLVIG-inoculated rabbits, compared with 6 (42.9%) of the 14 control rabbits, seroconverted for HTLV-I. Gene amplification detected the presence of HTLV-I proviral sequences in all of the seroconverted but in none of the seronegative rabbits. These results suggest that passive immunization is effective in preventing dam-to-offspring transmission of HTLV-I.

Entities: Disease Species

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Year: 1991 PMID： 1955718 DOI： 10.1093/infdis/164.6.1193

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

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Cited

15 in total

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3. Amino acid changes at positions 173 and 187 in the human T-cell leukemia virus type 1 surface glycoprotein induce specific neutralizing antibodies.

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Review 4. Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.

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5. Association between maternal antibodies to the external envelope glycoprotein and vertical transmission of human T-lymphotropic virus type I. Maternal anti-env antibodies correlate with protection in non-breast-fed children.

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10. The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice.

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Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type I in rabbits.

1. Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma.

Review 2. Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation.

3. Amino acid changes at positions 173 and 187 in the human T-cell leukemia virus type 1 surface glycoprotein induce specific neutralizing antibodies.

Review 4. Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.

5. Association between maternal antibodies to the external envelope glycoprotein and vertical transmission of human T-lymphotropic virus type I. Maternal anti-env antibodies correlate with protection in non-breast-fed children.

6. Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis.

Review 7. Molecular determinants of human T-lymphotropic virus type 1 transmission and spread.

8. Cellular Factors Involved in HTLV-1 Entry and Pathogenicit.

Review 9. Animal Models Utilized in HTLV-1 Research.

10. The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice.