Literature DB >> 19556993

Transplantation: To convert or not to convert: lessons from the CONVERT trial.

Suphamai Bunnapradist, Flavio Vincenti.   

Abstract

In participants of the CONVERT trial, which enrolled recipients of kidney transplants, conversion of immunosuppressive therapy from calcineurin inhibitors to sirolimus did not improve renal function. More importantly, the intervention was detrimental among patients with impaired kidney function and/or proteinuria. Sirolimus conversion resulted, however, in lower rates of malignancy.

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Year:  2009        PMID： 19556993     DOI： 10.1038/nrneph.2009.94

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN： 1759-5061            Impact factor:   28.314


  8 in total

1.  Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN').

Authors:  K Solez; R B Colvin; L C Racusen; B Sis; P F Halloran; P E Birk; P M Campbell; M Cascalho; A B Collins; A J Demetris; C B Drachenberg; I W Gibson; P C Grimm; M Haas; E Lerut; H Liapis; R B Mannon; P B Marcus; M Mengel; M J Mihatsch; B J Nankivell; V Nickeleit; J C Papadimitriou; J L Platt; P Randhawa; I Roberts; L Salinas-Madriga; D R Salomon; D Seron; M Sheaff; J J Weening
Journal:  Am J Transplant       Date:  2007-03       Impact factor: 8.086

Review 2.  Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review of the evidence.

Authors:  Atul V Mulay; Sandra Cockfield; Rod Stryker; Dean Fergusson; Greg A Knoll
Journal:  Transplantation       Date:  2006-11-15       Impact factor: 4.939

3.  Cyclosporine withdrawal from a mycophenolate mofetil-containing immunosuppressive regimen: results of a five-year, prospective, randomized study.

Authors:  Daniel Abramowicz; Maria Del Carmen Rial; Stefan Vitko; Domingo del Castillo; Derek Manas; Mieczyslaw Lao; Nesrin Gafner; Peter Wijngaard
Journal:  J Am Soc Nephrol       Date:  2005-05-25       Impact factor: 10.121

4.  Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients.

Authors:  Giovanni Stallone; Barbara Infante; Antonio Schena; Michele Battaglia; Pasquale Ditonno; Antonia Loverre; Loreto Gesualdo; Francesco Paolo Schena; Giuseppe Grandaliano
Journal:  J Am Soc Nephrol       Date:  2005-10-19       Impact factor: 10.121

5.  Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology.

Authors:  Brian J Nankivell; Richard J Borrows; Caroline L S Fung; Philip J O'Connell; Jeremy R Chapman; Richard D M Allen
Journal:  Transplantation       Date:  2004-08-27       Impact factor: 4.939

Review 6.  Malignancy in kidney transplant recipients.

Authors:  Anil Kapoor
Journal:  Drugs       Date:  2008       Impact factor: 9.546

Review 7.  mToR inhibitors-induced proteinuria: mechanisms, significance, and management.

Authors:  Emmanuel Letavernier; Christophe Legendre
Journal:  Transplant Rev (Orlando)       Date:  2008-04       Impact factor: 3.943

8.  Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial.

Authors:  Francesco P Schena; Michael D Pascoe; Josefina Alberu; Maria del Carmen Rial; Rainer Oberbauer; Daniel C Brennan; Josep M Campistol; Lorraine Racusen; Martin S Polinsky; Robert Goldberg-Alberts; Huihua Li; Joseph Scarola; John F Neylan
Journal:  Transplantation       Date:  2009-01-27       Impact factor: 4.939
  8 in total
  4 in total

Review 1.  Cancer in the transplant recipient.

Authors:  Jeremy R Chapman; Angela C Webster; Germaine Wong
Journal:  Cold Spring Harb Perspect Med       Date:  2013-07-01       Impact factor: 6.915

2.  Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in vivo rat model.

Authors:  José Sereno; Paulo Rodrigues-Santos; Helena Vala; Petronila Rocha-Pereira; Rui Alves; João Fernandes; Alice Santos-Silva; Eugénia Carvalho; Frederico Teixeira; Flávio Reis
Journal:  Int J Mol Sci       Date:  2014-05-20       Impact factor: 5.923

3.  A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology.

Authors:  R Brian Stevens; Kirk W Foster; Clifford D Miles; Andre C Kalil; Diana F Florescu; John P Sandoz; Theodore H Rigley; Tamer Malik; Lucile E Wrenshall
Journal:  PLoS One       Date:  2015-10-14       Impact factor: 3.240

4.  A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes.

Authors:  R Brian Stevens; Kirk W Foster; Clifford D Miles; James T Lane; Andre C Kalil; Diana F Florescu; John P Sandoz; Theodore H Rigley; Kathleen J Nielsen; Jill Y Skorupa; Anna M Kellogg; Tamer Malik; Lucile E Wrenshall
Journal:  Transplantation       Date:  2015-01       Impact factor: 4.939
  4 in total

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