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Literature DB >> 19556189

Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra.

Abstract

The unilateral injection of putative GABA agonists, muscimol, baclofen, imidazole acetic acid and GABA into the caudal area of substantia nigra (SN, zona reticulata) induced immediately a contralateral turning, whereas the antogonists picrotoxin and bicuculline methiodide induced ipsilateral turning. In the rostral area picrotoxin induced contralateral turning. Muscimol (10 ng bilaterally injected into SN) induced behavioural stimulation and antagonism of catelepsy in rats pretreated with high subcutaneous doses of perphenazine, haloperidol or reserpine and alpha-methyltyrosine. The muscimol behavioural stimulation seems dependent on a non-catecholaminergic neuronal pathway, probably present in the SN with GABA as the mediating neurotransmitter.

Entities: Chemical Disease Species

Year: 1977 PMID： 19556189 DOI： 10.1016/0304-3940(77)90183-5

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

50 in total

1. Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.

Authors: D Dybdal; K Gale
Journal: J Neurosci Date: 2000-09-01 Impact factor: 6.167

2. Effect of typical and atypical neuroleptics on the behavioural consequences of activation by muscimol of mesolimbic and nigro-striatal dopaminergic pathways in the rat.

Authors: N R Oakley; A G Hayes; M J Sheehan
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

3. Role of the cat substantia nigra pars reticulata in eye and head movements. II. Effects of local pharmacological injections.

Authors: D Boussaoud; J P Joseph
Journal: Exp Brain Res Date: 1985 Impact factor: 1.972

4. Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro.

Authors: I M Stanford; M G Lacey
Journal: J Neurosci Date: 1996-12-01 Impact factor: 6.167

5. Substantia nigra as an out-put station for striatal dopaminergic responses: role of a GABA-mediated inhibition of pars reticulata neurons.

Authors: G Di Chiara; M L Porceddu; M Morelli; M L Mulas; G L Gessa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-03 Impact factor: 3.000

Behavioural stimulation induced by muscimol and other GABA agonists injected into the substantia nigra.

1. Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.

2. Effect of typical and atypical neuroleptics on the behavioural consequences of activation by muscimol of mesolimbic and nigro-striatal dopaminergic pathways in the rat.

3. Role of the cat substantia nigra pars reticulata in eye and head movements. II. Effects of local pharmacological injections.

4. Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro.

5. Substantia nigra as an out-put station for striatal dopaminergic responses: role of a GABA-mediated inhibition of pars reticulata neurons.

6. Effect of intrastriatal administration of cholinergic and GABAergic agonists on apomorphine-induced circling.

Review 7. Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.

8. Behavioural effects mediated by unilateral nigral dopamine receptor stimulation in the rat.

9. Effect of sodium valproate on motor function regulated by the activation of GABA receptors.

Review 10. Physiological and behavioral studies with muscimol.