PURPOSE: To evaluate donor endothelial cell density (ECD) after Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Nonrandomized, prospective clinical study. METHODS: From a larger group of patients who underwent DMEK for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy, complete ECD measurements were available of 26 patients with 6 and 12 months of follow-up, of whom 7 also had 24 months of follow-up. RESULTS: For the group with 24 months of follow-up, ECD averaged 2700 (+/- 260) cells/mm(2) before surgery, 2200 (+/- 460) cells/mm(2) at 6 months after surgery, 2050 (+/- 330) cells/mm(2) at 12 months after surgery, and 1780 (+/- 390) cells/mm(2) at 24 months after surgery. For the group with 12 months of follow-up, ECD averaged 2620 (+/- 210) cells/mm(2) before surgery, 1850 (+/- 540) cells/mm(2) at 6 months after surgery, and 1680 (+/- 550) cells/mm(2) at 12 months after surgery. In both groups, the ECD decreased significantly between the preoperative and 6-month measurement (P < .05). CONCLUSIONS: Similar to earlier endothelial keratoplasty techniques, DMEK may be associated with a decrease in donor ECD of approximately 25% in the early postoperative phase.
PURPOSE: To evaluate donor endothelial cell density (ECD) after Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Nonrandomized, prospective clinical study. METHODS: From a larger group of patients who underwent DMEK for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy, complete ECD measurements were available of 26 patients with 6 and 12 months of follow-up, of whom 7 also had 24 months of follow-up. RESULTS: For the group with 24 months of follow-up, ECD averaged 2700 (+/- 260) cells/mm(2) before surgery, 2200 (+/- 460) cells/mm(2) at 6 months after surgery, 2050 (+/- 330) cells/mm(2) at 12 months after surgery, and 1780 (+/- 390) cells/mm(2) at 24 months after surgery. For the group with 12 months of follow-up, ECD averaged 2620 (+/- 210) cells/mm(2) before surgery, 1850 (+/- 540) cells/mm(2) at 6 months after surgery, and 1680 (+/- 550) cells/mm(2) at 12 months after surgery. In both groups, the ECD decreased significantly between the preoperative and 6-month measurement (P < .05). CONCLUSIONS: Similar to earlier endothelial keratoplasty techniques, DMEK may be associated with a decrease in donor ECD of approximately 25% in the early postoperative phase.
Authors: A-K B Maier; E Gundlach; J Gonnermann; M K J Klamann; E Bertelmann; P W Rieck; A M Joussen; N Torun Journal: Eye (Lond) Date: 2014-11-21 Impact factor: 3.775
Authors: Meraf A Wolle; David L DeMill; Lauren Johnson; Stephen I Lentz; Maria A Woodward; Shahzad I Mian Journal: Cornea Date: 2017-11 Impact factor: 2.651