UNLABELLED: Treatment success of cellulitis in the age of community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA). A comparison of initial antibiotic choice and treatment success in the pre- and post-CAMRSA eras. OBJECTIVE: The objective of this study is to determine antibiotic prescribing patterns and treatment failure rates for cellulitis in the pre- and post-CAMRSA eras. METHODS: We performed an electronic chart review of patients seen in our emergency department with cellulitis in 2000 and 2005. Inclusion criteria included age 18 years or more and received a single oral antibiotic for cellulitis. Exclusion criteria were incision and drainage, surgery, or admission on initial visit. Treatment failure was defined as a repeat visit in the subsequent 30 days and a change in antibiotics, admission to the hospital, incision and drainage of abscess, or surgical intervention. Antibiotic-prescribing practices and treatment failure rates were then compared in the pre- and post-CAMRSA eras. RESULTS: There was a significant decrease in beta-lactam antibiotics and an increase in CAMRSA-effective antibiotics prescribed in 2005 vs 2000. The difference in treatment failure rates of the beta-lactams and CAMRSA antibiotics was statistically insignificant. There has not been an increase in failure rates of the beta-lactam antibiotics for simple cellulitis since the emergence of CAMRSA. CONCLUSION: Our study demonstrates that prescribing practices for simple cellulitis have changed since the emergence of CAMRSA. This may not be appropriate because beta-lactam antibiotics perform as well as 'CAMRSA antibiotics' in our study.
UNLABELLED: Treatment success of cellulitis in the age of community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA). A comparison of initial antibiotic choice and treatment success in the pre- and post-CAMRSA eras. OBJECTIVE: The objective of this study is to determine antibiotic prescribing patterns and treatment failure rates for cellulitis in the pre- and post-CAMRSA eras. METHODS: We performed an electronic chart review of patients seen in our emergency department with cellulitis in 2000 and 2005. Inclusion criteria included age 18 years or more and received a single oral antibiotic for cellulitis. Exclusion criteria were incision and drainage, surgery, or admission on initial visit. Treatment failure was defined as a repeat visit in the subsequent 30 days and a change in antibiotics, admission to the hospital, incision and drainage of abscess, or surgical intervention. Antibiotic-prescribing practices and treatment failure rates were then compared in the pre- and post-CAMRSA eras. RESULTS: There was a significant decrease in beta-lactam antibiotics and an increase in CAMRSA-effective antibiotics prescribed in 2005 vs 2000. The difference in treatment failure rates of the beta-lactams and CAMRSA antibiotics was statistically insignificant. There has not been an increase in failure rates of the beta-lactam antibiotics for simple cellulitis since the emergence of CAMRSA. CONCLUSION: Our study demonstrates that prescribing practices for simple cellulitis have changed since the emergence of CAMRSA. This may not be appropriate because beta-lactam antibiotics perform as well as 'CAMRSA antibiotics' in our study.
Authors: Hermione J Hurley; Bryan C Knepper; Connie S Price; Philip S Mehler; William J Burman; Timothy C Jenkins Journal: Am J Med Date: 2013-12 Impact factor: 4.965
Authors: Julio Collazos; Belén de la Fuente; Alicia García; Helena Gómez; C Menéndez; Héctor Enríquez; Paula Sánchez; María Alonso; Ian López-Cruz; Manuel Martín-Regidor; Ana Martínez-Alonso; José Guerra; Arturo Artero; Marino Blanes; Javier de la Fuente; Víctor Asensi Journal: PLoS One Date: 2018-09-27 Impact factor: 3.240